{"id":"W2044592759","doi":"10.1038/sj.gt.3303100","title":"Progress and prospects: gene therapy for performance and appearance enhancement","year":2008,"lang":"en","type":"review","venue":"Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Heart, Lung, and Blood Institute; World Anti-Doping Agency","keywords":"Genetic enhancement; Performance enhancement; Human enhancement; Gene transfer; Hair growth; Reversing; Disease; Gene delivery; Psychological intervention; Cognition; Biology; Bioinformatics; Risk analysis (engineering); Psychology; Medicine; Neuroscience; Gene; Physical medicine and rehabilitation; Pathology; Genetics; Engineering; Physiology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003640432,0.0006890194,0.001009386,0.000116994,0.0002907574,0.00007081647,0.0004346127,0.0003944854,0.00001239301],"category_scores_gemma":[0.000007106948,0.0005492228,0.0002543112,0.0001735227,0.000357929,0.000007944514,0.0001095281,0.0002191155,0.000007291528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003808009,"about_ca_system_score_gemma":0.0003376256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001784126,"about_ca_topic_score_gemma":0.000002947191,"domain_scores_codex":[0.9973285,0.0001531294,0.0004814081,0.001073476,0.0002877368,0.0006758033],"domain_scores_gemma":[0.9986404,0.00001754706,0.0002587132,0.0007819441,0.0001361994,0.000165173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001551399,0.0001259729,0.00002556048,0.001084923,0.0004189335,0.000002662646,0.00005729318,5.379529e-7,0.01219787,0.000001787895,0.0002907938,0.9842423],"study_design_scores_gemma":[0.002038226,0.007116409,0.00002004524,0.000477516,0.0000239879,0.0001039248,0.000002464282,0.000009407082,0.09992673,0.00001078966,0.8896251,0.0006454372],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.08565561,0.9103698,0.00008022606,0.00003851984,0.0001072467,0.003637979,0.00006207922,0.00002455597,0.00002398451],"genre_scores_gemma":[0.0009845546,0.9941405,0.000822291,0.0001893137,0.0006555194,0.002221405,0.0002801549,0.0001673769,0.0005388569],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9835969,"threshold_uncertainty_score":0.999696,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03873682208817798,"score_gpt":0.3448344268297092,"score_spread":0.3060976047415312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}