{"id":"W2044592759","doi":"10.1038/sj.gt.3303100","title":"Progress and prospects: gene therapy for performance and appearance enhancement","year":2008,"lang":"en","type":"review","venue":"Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Heart, Lung, and Blood Institute; World Anti-Doping Agency","keywords":"Genetic enhancement; Performance enhancement; Human enhancement; Gene transfer; Hair growth; Reversing; Disease; Gene delivery; Psychological intervention; Cognition; Biology; Bioinformatics; Risk analysis (engineering); Psychology; Medicine; Neuroscience; Gene; Physical medicine and rehabilitation; Pathology; Genetics; Engineering; Physiology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000747967,0.001172773,0.001612316,0.001424476,0.000439521,0.001501552,0.001252873,0.002264126,0.003582138],"category_scores_gemma":[0.0005805471,0.0002880495,0.0004041348,0.001709393,0.001246585,0.002292576,0.0007233956,0.002812204,0.002781971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009487587,"about_ca_system_score_gemma":0.000991257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009337967,"about_ca_topic_score_gemma":0.001545405,"domain_scores_codex":[0.999804,0.00003568625,0.00001505272,0.0000420247,0.000076971,0.00002629821],"domain_scores_gemma":[0.9997587,0.0001437731,0.00001810666,0.00000985921,0.00004950168,0.00002011624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001077631,0.0001299842,0.0001651163,0.007951071,0.00003865145,0.0003628543,0.000109948,0.0006221838,0.01276206,0.0247462,0.04272145,0.9102827],"study_design_scores_gemma":[0.00001851723,0.00007814646,0.0002692616,0.0007473411,0.0000299437,0.001064347,0.00008165985,0.000183295,0.002494368,0.007886189,0.9871238,0.00002312977],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001601749,0.9963009,0.0006952044,0.0004871122,0.0005338301,0.000004514173,0.000009611783,0.00001358445,0.001794992],"genre_scores_gemma":[0.001706399,0.9938496,0.001102765,0.000610194,0.0004158484,0.0000169696,0.00002314113,0.00000512557,0.002270044],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003582138,"threshold_uncertainty_score":0.01198351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03873682208817798,"score_gpt":0.3448344268297092,"score_spread":0.3060976047415312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}