{"id":"W2044602856","doi":"10.1158/1535-7163.targ-13-c232","title":"Abstract C232: B-raf/Mek/Erk Pathway inhibition induces GPNMB expression and sensitizes melanoma cells to the antibody-drug conjugate glembatumumab vedotin.","year":2013,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Vemurafenib; Trametinib; Dabrafenib; Melanoma; Medicine; Cancer research; Selumetinib; Antibody-drug conjugate; MAPK/ERK pathway; Targeted therapy; MEK inhibitor; Cancer; Kinase; Antibody; Immunology; Internal medicine; Monoclonal antibody; Biology; KRAS; Metastatic melanoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006728793,0.0003675657,0.0001902883,0.000151959,0.0001652196,0.000186232,0.0001830375,0.0002550186,0.004041585],"category_scores_gemma":[0.00005106508,0.0001081129,0.000299833,0.0001784689,0.0001135402,0.0001046229,0.00009104465,0.0005933178,0.001022104],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003259497,"about_ca_system_score_gemma":0.0002381613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001710669,"about_ca_topic_score_gemma":0.001628453,"domain_scores_codex":[0.999913,0.000009742041,0.000006177235,0.00001649888,0.00002638622,0.00002817655],"domain_scores_gemma":[0.999969,0.000005377597,0.00000512204,0.000004620833,0.000005057492,0.00001087813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001981659,0.0001017352,0.00009377061,0.00004076938,0.000007732896,0.00005710051,0.000007238292,0.00004215314,0.9985012,0.00004494489,0.000276497,0.0006286819],"study_design_scores_gemma":[0.00008113165,0.0006629321,0.005964696,0.000006702119,0.00001382696,0.0003174494,0.00002374044,0.0006644923,0.9892154,0.00002564575,0.003019993,0.000003978057],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992368,0.001175174,0.0008759223,0.0001909646,0.00008722008,0.00007702235,0.001904269,0.00009102416,0.003230429],"genre_scores_gemma":[0.9876084,0.0007906756,0.001247149,0.00009116877,0.00001731513,0.00009389921,0.004197605,0.00002017488,0.00593364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004041585,"threshold_uncertainty_score":0.01352042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01418334216990621,"score_gpt":0.2751276714370866,"score_spread":0.2609443292671804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}