{"id":"W2044602856","doi":"10.1158/1535-7163.targ-13-c232","title":"Abstract C232: B-raf/Mek/Erk Pathway inhibition induces GPNMB expression and sensitizes melanoma cells to the antibody-drug conjugate glembatumumab vedotin.","year":2013,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Vemurafenib; Trametinib; Dabrafenib; Melanoma; Medicine; Cancer research; Selumetinib; Antibody-drug conjugate; MAPK/ERK pathway; Targeted therapy; MEK inhibitor; Cancer; Kinase; Antibody; Immunology; Internal medicine; Monoclonal antibody; Biology; KRAS; Metastatic melanoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001903578,0.0004539046,0.00046652,0.0001203181,0.0002422314,0.0001321182,0.0001643892,0.0001614926,0.0001733662],"category_scores_gemma":[0.00001102889,0.0003262165,0.0001243154,0.0002716743,0.0002013811,0.0002129228,0.0001178722,0.0004512511,0.00008942506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001501315,"about_ca_system_score_gemma":0.000157122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003278119,"about_ca_topic_score_gemma":0.0000433341,"domain_scores_codex":[0.9977912,0.0000927783,0.0004211551,0.0005901267,0.0005303192,0.000574422],"domain_scores_gemma":[0.9985475,0.00008325983,0.0002137054,0.0006361589,0.0002728613,0.0002465493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002298232,0.00007046556,0.000184711,0.00008197627,0.0001633658,0.00006402659,0.001665784,0.0001215438,0.9495526,0.00005478407,0.0001752473,0.0476357],"study_design_scores_gemma":[0.001805143,0.000158044,0.007795193,0.0005097687,0.0001192065,0.00006122769,0.0007280115,0.0001144591,0.9654017,0.0004820871,0.02240183,0.0004232968],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815995,0.00734659,0.001217338,0.007618462,0.0004132916,0.001300258,0.00006327642,0.0001363546,0.0003049724],"genre_scores_gemma":[0.9875133,0.0005709292,0.001164238,0.009893807,0.0003046739,0.0001946628,0.00003884936,0.0001131919,0.0002063312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0472124,"threshold_uncertainty_score":0.999919,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01418334216990621,"score_gpt":0.2751276714370866,"score_spread":0.2609443292671804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}