{"id":"W2044627177","doi":"10.1038/sj.onc.1208286","title":"Retinoic acid targets DNA-methyltransferases and histone deacetylases during APL blast differentiation in vitro and in vivo","year":2005,"lang":"en","type":"article","venue":"Oncogene","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Biology; DNA methylation; Histone methyltransferase; Methyltransferase; Retinoic acid; Cellular differentiation; Cancer research; Histone deacetylase; Epigenetics; Acute promyelocytic leukemia; Molecular biology; Chromatin; DNA methyltransferase; Tretinoin; Histone; Methylation; Cell culture; Gene expression; Genetics; DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001051106,0.000166141,0.0001779131,0.00008126679,0.00005263054,0.00002022276,0.00007377018,0.000140351,0.00001959478],"category_scores_gemma":[0.0000529259,0.0001688161,0.00002969925,0.00008208063,0.00007535943,0.00001017211,0.00005439994,0.00009064481,0.000001186636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004498892,"about_ca_system_score_gemma":0.000035738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001916775,"about_ca_topic_score_gemma":0.0002130587,"domain_scores_codex":[0.9990304,0.00005546606,0.0002256606,0.0003674812,0.00009150312,0.0002294734],"domain_scores_gemma":[0.9997174,0.00001224619,0.0000448003,0.0001403838,0.00002185994,0.00006338191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002002966,0.00006546727,0.004318644,0.00007111543,0.000009707971,0.000008295365,0.00009801354,0.00001624812,0.9921898,0.000002075324,0.00002164627,0.002998685],"study_design_scores_gemma":[0.001112049,0.00006349808,0.004687249,0.00002804022,0.0000113794,0.00002784709,0.00004639451,0.00005637934,0.992416,0.00001501567,0.001343041,0.0001931488],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876112,0.01172654,0.000173016,0.00009560261,0.00003593266,0.000121501,0.00001427663,0.000009497266,0.0002124756],"genre_scores_gemma":[0.9957898,0.003046034,0.0006228705,0.0000632584,0.0001390657,0.00002516714,0.00004878737,0.00002029101,0.0002447011],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008680509,"threshold_uncertainty_score":0.6884121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00440553168674767,"score_gpt":0.2254468280050141,"score_spread":0.2210412963182665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}