{"id":"W2044637592","doi":"10.1038/sj.emboj.7601247","title":"Intersectin‐1L nucleotide exchange factor regulates secretory granule exocytosis by activating Cdc42","year":2006,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; Centre National de la Recherche Scientifique; Institut National de la Santé et de la Recherche Médicale","keywords":"Exocytosis; Guanine nucleotide exchange factor; Neurotransmission; Biology; Secretion; Endocrinology; Cell biology; Genetics; GTPase; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001930009,0.0004432736,0.0003311542,0.0005543024,0.0007878146,0.001274902,0.0003736045,0.0005348641,0.001720996],"category_scores_gemma":[0.000286256,0.0003255348,0.0002846968,0.0002905384,0.0004759448,0.0006019461,0.0006360727,0.0008651604,0.0005988195],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001826138,"about_ca_system_score_gemma":0.0003945288,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001176375,"about_ca_topic_score_gemma":0.002046676,"domain_scores_codex":[0.9997677,0.00003041591,0.00001482062,0.00004715673,0.00004331263,0.00009670157],"domain_scores_gemma":[0.9998372,0.00002171644,0.0000427544,0.0000219483,0.00001844348,0.00005788649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004781417,0.00001980533,0.0005122899,0.00002774482,0.000006395589,0.0002160593,0.00002914709,0.0001169631,0.9967245,0.0009335959,0.000126784,0.0008084847],"study_design_scores_gemma":[0.00006907556,0.00007745803,0.01363172,0.00001180905,0.00002302865,0.0006011444,0.0001318526,0.002604557,0.9777003,0.0003777965,0.004757856,0.0000132983],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938036,0.002063003,0.001065518,0.0001664469,0.00002881028,0.000009256338,0.0002368512,0.00009818984,0.002528225],"genre_scores_gemma":[0.9966465,0.000381819,0.0005867981,0.00002729007,0.000007107655,0.00001286424,0.000288694,0.00002566992,0.002023202],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001826138,"threshold_uncertainty_score":0.01324964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008076574193606417,"score_gpt":0.2071120143534432,"score_spread":0.1990354401598368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}