{"id":"W2044699816","doi":"10.1016/j.bmcl.2009.02.075","title":"Synthesis and evaluation of lysine derived sulfamides as histone deacetylase inhibitors","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"Pyrogenesis (Canada)","funders":"","keywords":"Sulfamide; HDAC1; Chemistry; Lysine; HDAC6; Histone deacetylase; Enzyme; Biochemistry; Metabolic stability; Potency; HDAC8; Hydroxamic acid; Pharmacology; Stereochemistry; Histone; Amino acid; In vitro; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004210346,0.0004763303,0.0003311631,0.0003374305,0.0002251208,0.0002135841,0.0003930244,0.0002843357,0.001809226],"category_scores_gemma":[0.0002184415,0.0001554143,0.0002914142,0.0002516389,0.0001935947,0.0003013216,0.0002098057,0.0003319121,0.0004021048],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003118133,"about_ca_system_score_gemma":0.000334936,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006746125,"about_ca_topic_score_gemma":0.001299681,"domain_scores_codex":[0.9998735,0.00002655099,0.00001407399,0.0000155616,0.00003085187,0.00003939562],"domain_scores_gemma":[0.9999136,0.00001187503,0.0000165732,0.000009736372,0.00002444105,0.0000238185],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009150721,0.0005039714,0.0003966022,0.000455819,0.00006724556,0.0005381253,0.0001589919,0.003272412,0.9568028,0.001821525,0.0007706404,0.0342967],"study_design_scores_gemma":[0.0002336504,0.004841862,0.001023461,0.00002675304,0.00007740215,0.0002841041,0.00004204832,0.001117064,0.9771131,0.0001617807,0.01505946,0.00001924475],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9559389,0.01124737,0.01390504,0.0003085838,0.000187515,0.0004274116,0.0009116401,0.0001979743,0.01687561],"genre_scores_gemma":[0.9800091,0.008191999,0.006078503,0.00009489102,0.00004211594,0.00008469938,0.000611903,0.00002491342,0.004861841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001809226,"threshold_uncertainty_score":0.006052494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01348216570755414,"score_gpt":0.2914858391354335,"score_spread":0.2780036734278794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}