{"id":"W2044708845","doi":"10.1016/j.jbiotec.2007.05.009","title":"Sugar-mediated lyoprotection of purified human CYP3A4 and CYP2D6","year":2007,"lang":"en","type":"article","venue":"Journal of Biotechnology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Merck Canada; Vanderbilt University","keywords":"Trehalose; Sorbitol; Mannitol; Enzyme; Chemistry; Sugar; Biochemistry; Sucrose; Anhydrous; CYP3A4; Enzyme assay; Chromatography; Cytochrome P450; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001360673,0.0004409393,0.0002375714,0.0001350641,0.0001373587,0.0002358494,0.0001979412,0.0001828102,0.003446517],"category_scores_gemma":[0.0002090527,0.0001212986,0.0003059895,0.0001866247,0.0001736594,0.0001075669,0.0002023869,0.0005800157,0.0004964333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002502364,"about_ca_system_score_gemma":0.0003408595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001687602,"about_ca_topic_score_gemma":0.002126515,"domain_scores_codex":[0.999907,0.00002449933,0.000005905453,0.00001248531,0.00001656963,0.0000334281],"domain_scores_gemma":[0.999943,0.00001507665,0.00001085369,0.000008674551,0.000007762244,0.00001466847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001301269,0.0001834155,0.0004238609,0.0000736064,0.00003765102,0.0001045438,0.00003268745,0.0002934627,0.9907433,0.000426552,0.000349567,0.006030063],"study_design_scores_gemma":[0.00006793331,0.0004578147,0.001522091,0.000003361037,0.00001841426,0.0001238224,0.00001259594,0.0007086037,0.9947448,0.00003142359,0.002305717,0.000003513171],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931584,0.0013616,0.002808127,0.0001738651,0.00009725138,0.00005520793,0.0004972402,0.0001027971,0.001745556],"genre_scores_gemma":[0.9904688,0.0007254469,0.001740789,0.00007393124,0.00002753849,0.00002752589,0.001624598,0.00002712826,0.005284275],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003446517,"threshold_uncertainty_score":0.01152974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07037182869266764,"score_gpt":0.4233322310347143,"score_spread":0.3529604023420467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}