{"id":"W2044708845","doi":"10.1016/j.jbiotec.2007.05.009","title":"Sugar-mediated lyoprotection of purified human CYP3A4 and CYP2D6","year":2007,"lang":"en","type":"article","venue":"Journal of Biotechnology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Merck Canada; Vanderbilt University","keywords":"Trehalose; Sorbitol; Mannitol; Enzyme; Chemistry; Sugar; Biochemistry; Sucrose; Anhydrous; CYP3A4; Enzyme assay; Chromatography; Cytochrome P450; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001916827,0.0001720799,0.000437367,0.0006531487,0.0001234754,0.000006104029,0.0002816213,0.0008494551,0.0001724435],"category_scores_gemma":[0.0001731777,0.0001525665,0.0001108091,0.0003560757,0.000453903,0.00006688543,0.00008885748,0.001266499,0.000007705143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003417377,"about_ca_system_score_gemma":0.00005313537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000115648,"about_ca_topic_score_gemma":0.0000150845,"domain_scores_codex":[0.9983534,0.0001398656,0.0008177198,0.0001642835,0.0001675341,0.0003572103],"domain_scores_gemma":[0.998556,0.0001833097,0.0007633972,0.0001421851,0.0001742436,0.0001809222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003461021,0.000200675,0.001956486,0.00002728865,0.0001810714,0.00008174672,0.0001728233,0.00001475408,0.9580073,0.001589844,0.0003592682,0.0370626],"study_design_scores_gemma":[0.002319446,0.0004360736,0.007101725,0.00001235158,0.0001532907,0.0003634825,0.0001570698,0.00004743012,0.9185407,0.001745933,0.06898356,0.0001389598],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992667,0.003111001,0.0009966523,0.001276941,0.001040598,0.0001764775,0.0000140769,0.00003600364,0.0006813174],"genre_scores_gemma":[0.9970242,0.001742562,0.0005353211,0.0003387523,0.0002673291,0.000001764823,0.000002190571,0.00001729798,0.00007056401],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06862429,"threshold_uncertainty_score":0.6551775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07037182869266764,"score_gpt":0.4233322310347143,"score_spread":0.3529604023420467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}