{"id":"W2044722937","doi":"10.1074/jbc.m405594200","title":"Pseudomonas aeruginosa Exotoxin A Induces Human Mast Cell Apoptosis by a Caspase-8 and -3-dependent Mechanism","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Food Allergy and Anaphylaxis Research","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"Pseudomonas exotoxin; Pseudomonas aeruginosa; Exotoxin; Apoptosis; Microbiology; Mechanism (biology); Mast cell; Chemistry; Caspase; Cell biology; Caspase 1; Pseudomonas; Programmed cell death; Biology; Bacteria; Immunology; Biochemistry; Toxin; Physics; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002824563,0.0001692438,0.0003587775,0.00004031891,0.00009474995,0.00002847596,0.0001584281,0.0002781171,0.0003150859],"category_scores_gemma":[0.00007949847,0.0001107024,0.0001411821,0.00009655097,0.0001438356,0.00004522325,0.00008133981,0.0006806928,0.0000053885],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007676224,"about_ca_system_score_gemma":0.00007884402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001400189,"about_ca_topic_score_gemma":7.48679e-7,"domain_scores_codex":[0.9987793,0.00002728232,0.0003634989,0.0002101686,0.0003429874,0.0002767792],"domain_scores_gemma":[0.9991956,0.00003900566,0.0001839485,0.0001184255,0.0001058783,0.0003571436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001355343,0.0004198666,0.0001961268,0.00006254945,0.00005691759,0.000236756,0.00004061721,8.552689e-7,0.9983084,0.00003761794,0.000251069,0.0002536424],"study_design_scores_gemma":[0.002043104,0.001088752,0.0003145296,0.00009770985,0.000009846511,0.0006699944,0.0003904832,7.216765e-7,0.9940147,0.0008580767,0.0003844102,0.0001276577],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996784,0.0007662037,0.00004285025,0.001024906,0.00002499096,0.0000705645,0.000009741011,0.00001278414,0.001263964],"genre_scores_gemma":[0.9984742,0.000480122,0.0002777167,0.0001652173,0.0002134077,0.000003573705,0.000009102043,0.000009007303,0.0003676744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004293734,"threshold_uncertainty_score":0.4514314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03022418245021224,"score_gpt":0.2797157158823433,"score_spread":0.2494915334321311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}