{"id":"W2044757846","doi":"10.1371/journal.pone.0090439","title":"Suppression of Immunodominant Antitumor and Antiviral CD8+ T Cell Responses by Indoleamine 2,3-Dioxygenase","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; Western University","funders":"National Cancer Institute; Ontario Ministry of Research and Innovation; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Indoleamine 2,3-dioxygenase; Kynurenine; Biology; FOXP3; Subdominant; Influenza A virus; Immunology; Antigen; Cytotoxic T cell; Epitope; Immunodominance; CD8; Virus; Virology; Immune system; In vitro; Genetics; Tryptophan","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001294593,0.0005051912,0.0003073713,0.0002791729,0.000079128,0.0002152446,0.0001893278,0.0003036727,0.0008427463],"category_scores_gemma":[0.0001004392,0.0001482259,0.0002627797,0.00009370032,0.0002791335,0.0001862401,0.0001774737,0.0007574297,0.0002959309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001993756,"about_ca_system_score_gemma":0.0001825098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002021231,"about_ca_topic_score_gemma":0.0003440212,"domain_scores_codex":[0.9998099,0.00002810658,0.00001908227,0.00004047973,0.00003565646,0.00006683291],"domain_scores_gemma":[0.999843,0.00001736896,0.00005078427,0.00001886585,0.00001024641,0.00005970607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001936408,0.00003984941,0.0001635481,0.00001734234,0.000001651583,0.0000222065,0.000006017154,0.00002444083,0.9989247,0.00003215271,0.00000840674,0.0005660388],"study_design_scores_gemma":[0.00007707943,0.001523712,0.005119831,0.000007101834,0.00002117385,0.000342187,0.00003566519,0.000763926,0.990974,0.00006589823,0.001064966,0.000004608603],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972344,0.0005315365,0.001094465,0.00003492145,0.00001937196,0.00002686908,0.0002057176,0.00004852406,0.0008041948],"genre_scores_gemma":[0.9963022,0.0003836406,0.001421847,0.00004401128,0.00001529123,0.00005085333,0.0003096263,0.00001494794,0.001457406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008427463,"threshold_uncertainty_score":0.0028193,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02536459755828014,"score_gpt":0.2241694280203871,"score_spread":0.198804830462107,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}