{"id":"W2044762426","doi":"10.1002/jcp.22220","title":"High expression of IMPACT protein promotes resistance to indoleamine 2,3‐dioxygenase‐induced cell death","year":2010,"lang":"en","type":"article","venue":"Journal of Cellular Physiology","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Jurkat cells; Indoleamine 2,3-dioxygenase; Immune system; Cell biology; Apoptosis; Cytotoxic T cell; Biology; T cell; Chemistry; Cancer research; Immunology; Tryptophan; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007146555,0.0002327776,0.0002387786,0.0001283204,0.0001271594,0.0003000262,0.0001019562,0.000199376,0.001218089],"category_scores_gemma":[0.00006866399,0.0001003067,0.000223319,0.0001185709,0.0001469027,0.0001182622,0.0001947162,0.0004937264,0.0003690211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002193393,"about_ca_system_score_gemma":0.0001330313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003750215,"about_ca_topic_score_gemma":0.0005625354,"domain_scores_codex":[0.9998648,0.00001361405,0.00001072104,0.00002522842,0.00003756887,0.0000480068],"domain_scores_gemma":[0.9999164,0.00001251761,0.00002067399,0.00001189912,0.000007780418,0.00003080198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006862974,0.00002242547,0.0001177753,0.00001375868,0.000002110888,0.00003135495,0.000008132974,0.00001259307,0.9994277,0.00002204939,0.00001847021,0.0002548496],"study_design_scores_gemma":[0.00001102007,0.0003708821,0.005822018,0.000004056236,0.00001118843,0.0001935953,0.00003858894,0.0005769537,0.9912263,0.00002155281,0.001720846,0.000002958174],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967727,0.0007767049,0.001272977,0.00004935916,0.00002574834,0.00002150665,0.0002002314,0.00005107419,0.0008296185],"genre_scores_gemma":[0.9959187,0.0004428335,0.0007742058,0.00002632072,0.000006214383,0.00001844991,0.00050234,0.000009192658,0.002301815],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001218089,"threshold_uncertainty_score":0.004074872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01586867424673736,"score_gpt":0.2555487582135605,"score_spread":0.2396800839668231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}