{"id":"W2044762426","doi":"10.1002/jcp.22220","title":"High expression of IMPACT protein promotes resistance to indoleamine 2,3‐dioxygenase‐induced cell death","year":2010,"lang":"en","type":"article","venue":"Journal of Cellular Physiology","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Jurkat cells; Indoleamine 2,3-dioxygenase; Immune system; Cell biology; Apoptosis; Cytotoxic T cell; Biology; T cell; Chemistry; Cancer research; Immunology; Tryptophan; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002458831,0.0002026959,0.0004562974,0.0002074754,0.0000666769,0.00001501627,0.0005367939,0.0001458281,0.0001533563],"category_scores_gemma":[0.0005413954,0.0001444421,0.0002056728,0.0002627402,0.00008323132,0.000153656,0.00008576023,0.0005155986,0.00001751327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002042418,"about_ca_system_score_gemma":0.0001277937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008075314,"about_ca_topic_score_gemma":0.000004020779,"domain_scores_codex":[0.9983431,0.0002203443,0.0005303975,0.0002719529,0.0003077054,0.0003265519],"domain_scores_gemma":[0.9985182,0.000134712,0.0006634395,0.000356358,0.0001376847,0.0001896352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004817699,0.0003151386,0.00001295348,0.00004859221,0.000004658673,0.00002845881,0.000136519,0.00002563342,0.9984255,0.0001761961,0.0002175795,0.000127006],"study_design_scores_gemma":[0.0008657592,0.0007989993,0.00414545,0.00006513028,0.000003582194,0.00001156967,0.00002266564,0.000006907207,0.991859,0.001855682,0.0002184949,0.0001467476],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988642,0.00004385179,0.0001743147,0.0001434857,0.000262236,0.0003060613,0.00001014917,0.00001256925,0.0001831588],"genre_scores_gemma":[0.9977231,0.000004973012,0.001676888,0.00009756953,0.0002356745,0.000005683613,0.000001228151,0.00002511798,0.0002297818],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006566483,"threshold_uncertainty_score":0.5890177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01586867424673736,"score_gpt":0.2555487582135605,"score_spread":0.2396800839668231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}