{"id":"W2044764720","doi":"10.1182/blood-2006-04-017434","title":"Loss of SHP1 enhances JAK3/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK+ anaplastic large-cell lymphoma","year":2006,"lang":"en","type":"article","venue":"Blood","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":176,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Anaplastic large-cell lymphoma; Anaplastic lymphoma kinase; Cancer research; Chemistry; Cell culture; Transfection; MG132; Proteasome inhibitor; Molecular biology; Apoptosis; Biology; Lymphoma; Internal medicine; Biochemistry; Medicine; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001257848,0.0002901205,0.0002913395,0.0002179034,0.0001721863,0.0002988615,0.0001729711,0.0002486558,0.001347367],"category_scores_gemma":[0.0001126235,0.0001730113,0.0002492453,0.0001910564,0.0002209114,0.0002050378,0.0002053181,0.0005589079,0.0004487449],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002873682,"about_ca_system_score_gemma":0.0001891966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005696578,"about_ca_topic_score_gemma":0.0009995683,"domain_scores_codex":[0.9998585,0.00002141237,0.00001554985,0.00002219945,0.00004167171,0.00004065944],"domain_scores_gemma":[0.9998987,0.00002045503,0.00002982404,0.000009223974,0.000006865405,0.00003496079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001395576,0.00005010293,0.0001957531,0.00003287062,0.000005540975,0.00005228351,0.00001117094,0.00005559668,0.9987116,0.00003562564,0.00004953872,0.0006604067],"study_design_scores_gemma":[0.00003809507,0.0005039893,0.007701547,0.000004163949,0.0000203121,0.0003641996,0.00003672824,0.001223982,0.9885411,0.00003524811,0.00152623,0.000004615308],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99783,0.0007957062,0.0004735205,0.00007104138,0.00001412896,0.00001071379,0.0002312028,0.00004970828,0.0005238216],"genre_scores_gemma":[0.9971989,0.0005037023,0.0005004535,0.00003601007,0.000007043814,0.00002503728,0.0005184915,0.00001096515,0.001199298],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001347367,"threshold_uncertainty_score":0.004507363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008221777847802248,"score_gpt":0.2319301064359584,"score_spread":0.2237083285881561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}