{"id":"W2044822419","doi":"10.1021/bi0513812","title":"Conjoined Hemoglobins. Loss of Cooperativity and Protein−Protein Interactions","year":2005,"lang":"en","type":"article","venue":"Biochemistry","topic":"Hemoglobin structure and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Cooperativity; Chemistry; Cooperative binding; Hemoglobin; Protein subunit; Oxygen; Crystallography; Stereochemistry; Reagent; Biophysics; Binding site; Biochemistry; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003327686,0.0002984008,0.0001540505,0.0001871148,0.0001540803,0.000239805,0.0002752371,0.0003622237,0.0005242135],"category_scores_gemma":[0.0004589184,0.000181493,0.0001559416,0.000178073,0.0002699129,0.000269658,0.0002022164,0.0005595789,0.0001320609],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004906116,"about_ca_system_score_gemma":0.0001101829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007666002,"about_ca_topic_score_gemma":0.001046574,"domain_scores_codex":[0.999607,0.0000661368,0.00003053345,0.00009025959,0.000152272,0.00005379489],"domain_scores_gemma":[0.9994529,0.0001397448,0.000177173,0.00007090573,0.00005603663,0.0001033316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005644713,0.00001972219,0.0001881367,0.00001147373,0.000006117525,0.00002312039,0.000009714605,0.0001007455,0.9988987,0.00008498572,0.00001991761,0.0005809041],"study_design_scores_gemma":[0.000006945567,0.0001590498,0.003198996,0.000002835878,0.00001262751,0.0001379504,0.00001012352,0.00157508,0.9942718,0.00006705421,0.0005535631,0.000003847174],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950308,0.0005933805,0.003345393,0.00005307037,0.00001751905,0.00001852991,0.00006945233,0.00003387316,0.0008379381],"genre_scores_gemma":[0.9950268,0.0002256649,0.003154623,0.00006662999,0.000006034661,0.00001546497,0.0001739156,0.00001330071,0.001317574],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007666002,"threshold_uncertainty_score":0.003559589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005306347523483652,"score_gpt":0.2306986968767626,"score_spread":0.2253923493532789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}