{"id":"W2044822419","doi":"10.1021/bi0513812","title":"Conjoined Hemoglobins. Loss of Cooperativity and Protein−Protein Interactions","year":2005,"lang":"en","type":"article","venue":"Biochemistry","topic":"Hemoglobin structure and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Cooperativity; Chemistry; Cooperative binding; Hemoglobin; Protein subunit; Oxygen; Crystallography; Stereochemistry; Reagent; Biophysics; Binding site; Biochemistry; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007406982,0.0001513651,0.0001413565,0.00001708616,0.00006095825,0.00001509111,0.00008589757,0.0001521173,0.00006825107],"category_scores_gemma":[0.00008369239,0.000145092,0.00005529407,0.00006524373,0.00013836,0.0000066653,0.00007761377,0.00009719133,0.000005255381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001787797,"about_ca_system_score_gemma":0.00007501544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001046637,"about_ca_topic_score_gemma":0.000006358161,"domain_scores_codex":[0.9992398,0.00002029792,0.0001992895,0.000298512,0.00008802424,0.0001540657],"domain_scores_gemma":[0.9994354,0.00000423303,0.00008683075,0.0002889438,0.0001033262,0.0000812568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008375538,0.0000483985,0.0004851668,0.00004999928,0.00003032128,9.678267e-7,0.00001180752,0.00000315252,0.9953978,0.00005258934,0.001065958,0.002770063],"study_design_scores_gemma":[0.0004413331,0.0000719348,0.0003875122,0.00002690892,0.000009893551,0.00004177996,0.00002043841,0.00002653413,0.9685317,0.00002003068,0.03026975,0.0001521462],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949021,0.0003327375,0.0006765136,0.0002416443,0.00004328967,0.000185239,0.0000410916,0.00001546842,0.003561922],"genre_scores_gemma":[0.9947835,0.0000138185,0.001146374,0.0001002197,0.0003477639,0.00002728212,0.000095629,0.00001334319,0.003472079],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02920379,"threshold_uncertainty_score":0.5916681,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005306347523483652,"score_gpt":0.2306986968767626,"score_spread":0.2253923493532789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}