{"id":"W2044825067","doi":"10.1016/j.ejps.2010.08.009","title":"Pharmacological effect of orally delivered insulin facilitated by multilayered stable nanoparticles","year":2010,"lang":"en","type":"article","venue":"European Journal of Pharmaceutical Sciences","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":114,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada; Universidade de Coimbra","keywords":"Insulin; Nanoparticle; Pharmacology; Orally active; Chemistry; Medicine; Nanotechnology; Oral administration; Internal medicine; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00905476,0.0003784852,0.0006770046,0.000188859,0.0003686796,0.00005218749,0.001263381,0.0001382826,0.002341409],"category_scores_gemma":[0.001033344,0.0002675664,0.0002527154,0.0006710271,0.001855116,0.0005379353,0.0002124463,0.001795782,0.0002000726],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004921341,"about_ca_system_score_gemma":0.0001222031,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006091715,"about_ca_topic_score_gemma":0.000001809088,"domain_scores_codex":[0.9925954,0.004064336,0.00138912,0.0004277444,0.0007322837,0.0007911001],"domain_scores_gemma":[0.9960408,0.00179905,0.0007957637,0.0001549686,0.000397439,0.0008119511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001566162,0.0004195973,0.004924193,0.00004526607,0.0001687746,0.0002206021,0.00029087,0.001864605,0.9342242,0.00004312154,0.004401867,0.05183068],"study_design_scores_gemma":[0.005610746,0.00207343,0.0005926276,0.00003122745,0.0002617047,0.0001843853,0.0001256233,0.008386524,0.8251632,0.00001912029,0.1572264,0.0003249663],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992426,0.001877898,0.0002286352,0.0005065185,0.002248418,0.000404615,0.0001007954,0.0000614028,0.002145662],"genre_scores_gemma":[0.9976242,0.000370567,0.001126204,0.0004604534,0.000245297,0.000004030717,0.000002560881,0.00002608568,0.0001406653],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1528246,"threshold_uncertainty_score":0.9999776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09189483840030126,"score_gpt":0.428869385334046,"score_spread":0.3369745469337447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}