{"id":"W2044826456","doi":"10.1126/science.1093941","title":"Curcumin, a Major Constituent of Turmeric, Corrects Cystic Fibrosis Defects","year":2004,"lang":"en","type":"article","venue":"Science","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":561,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences","keywords":"Curcumin; Cystic fibrosis transmembrane conductance regulator; ΔF508; Cystic fibrosis; Endoplasmic reticulum; Hamster; Transfection; Mutation; Chemistry; Molecular biology; Biology; Endocrinology; Cell biology; Gene; Pharmacology; Internal medicine; Biochemistry; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009964115,0.0003700222,0.0003760411,0.0004964231,0.0001677767,0.0002080134,0.0001466821,0.0003485047,0.001760021],"category_scores_gemma":[0.0001355652,0.00009324475,0.0002277919,0.0001531419,0.0001946421,0.0001703865,0.0001702968,0.0003937073,0.0007812488],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001534899,"about_ca_system_score_gemma":0.000181379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004920231,"about_ca_topic_score_gemma":0.001049476,"domain_scores_codex":[0.9999572,0.00001124667,0.000002509041,0.00001132613,0.000009636942,0.00000810307],"domain_scores_gemma":[0.9999393,0.000009991502,0.00001764415,0.000005893874,0.00001026974,0.00001688457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006581356,0.0001845641,0.0004092812,0.0005843514,0.0000532506,0.0002359496,0.00002702441,0.0001083567,0.943396,0.000207769,0.001158434,0.05297688],"study_design_scores_gemma":[0.000176623,0.004234232,0.01336244,0.00009338176,0.0002566566,0.002172327,0.00007335087,0.0003690814,0.8973761,0.0003185011,0.08153318,0.0000342117],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8898902,0.08477595,0.009942207,0.001724922,0.0006824175,0.0001994585,0.0007340288,0.001277918,0.01077283],"genre_scores_gemma":[0.9461845,0.03126623,0.007497495,0.0004599906,0.0001598015,0.00006363586,0.0006989415,0.0001018683,0.01356758],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001760021,"threshold_uncertainty_score":0.005887806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01121750691745472,"score_gpt":0.3057962313952892,"score_spread":0.2945787244778345,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}