{"id":"W2044826456","doi":"10.1126/science.1093941","title":"Curcumin, a Major Constituent of Turmeric, Corrects Cystic Fibrosis Defects","year":2004,"lang":"en","type":"article","venue":"Science","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":561,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences","keywords":"Curcumin; Cystic fibrosis transmembrane conductance regulator; ΔF508; Cystic fibrosis; Endoplasmic reticulum; Hamster; Transfection; Mutation; Chemistry; Molecular biology; Biology; Endocrinology; Cell biology; Gene; Pharmacology; Internal medicine; Biochemistry; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003778711,0.0001176213,0.0002498437,0.0002386492,0.0001343676,0.00002761149,0.0002726303,0.00002707017,0.00007031054],"category_scores_gemma":[0.002688241,0.00009368901,0.00006231525,0.001357724,0.002262637,0.000211931,0.000116728,0.0001267595,0.00009990025],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002070479,"about_ca_system_score_gemma":0.00120946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009121651,"about_ca_topic_score_gemma":0.000008732311,"domain_scores_codex":[0.9979514,0.00001506131,0.000216356,0.0003699285,0.0009697919,0.0004774977],"domain_scores_gemma":[0.9987849,0.0001519932,0.00008315918,0.0003750885,0.0002821011,0.0003227346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001587222,0.0001621063,0.006050055,0.0002007403,0.000008030684,0.00006634233,0.0002525169,0.0002495873,0.9887583,0.0009168289,0.0001274699,0.00304931],"study_design_scores_gemma":[0.002742137,0.001658315,0.06991804,0.001129782,0.00006374624,0.0004718254,0.0003845488,0.0004280607,0.9177195,0.002309024,0.002894295,0.0002807381],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990047,0.001139091,0.004680485,0.0002641632,0.0003656952,0.0004829047,0.00001403282,0.00005239621,0.002954212],"genre_scores_gemma":[0.9826031,0.00001584816,0.01711433,0.0001002473,0.00003288572,0.00001669903,0.000002323733,0.000007662379,0.0001069149],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0710388,"threshold_uncertainty_score":0.8336778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01121750691745472,"score_gpt":0.3057962313952892,"score_spread":0.2945787244778345,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}