{"id":"W2044826629","doi":"10.1128/jvi.77.13.7341-7351.2003","title":"Lentivirus Vectors Incorporating the Immunoglobulin Heavy Chain Enhancer and Matrix Attachment Regions Provide Position-Independent Expression in B Lymphocytes","year":2003,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; University of California, Los Angeles; University of Toronto; Immune Deficiency Foundation; U.S. Department of Health and Human Services","keywords":"Biology; Molecular biology; Scaffold/matrix attachment region; Lentivirus; Enhancer; Immunoglobulin heavy chain; Phosphoglycerate kinase; Viral vector; Transgene; Haematopoiesis; Cell sorting; Antibody; Virology; Stem cell; Gene expression; Cell biology; Virus; Flow cytometry; Gene; Genetics; Recombinant DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003396466,0.00033539,0.0002289197,0.000294546,0.0001912671,0.0006204702,0.0003413513,0.0004054109,0.0008461762],"category_scores_gemma":[0.0002110074,0.0002207539,0.0002752788,0.0001319804,0.0002686644,0.0003218425,0.0002657084,0.0009651253,0.0004374284],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002418576,"about_ca_system_score_gemma":0.0002333885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004090571,"about_ca_topic_score_gemma":0.0005110145,"domain_scores_codex":[0.9996983,0.00006131043,0.0000360931,0.00006179188,0.00009531447,0.00004719385],"domain_scores_gemma":[0.9998274,0.0000411094,0.00004322768,0.00003430108,0.00002533008,0.00002857243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003232161,0.00002965355,0.0001741768,0.00002472339,0.000004488341,0.00004513769,0.00001533967,0.00005830147,0.9972844,0.0003002272,0.00002936857,0.002001764],"study_design_scores_gemma":[0.00002430302,0.0002257547,0.001203536,0.000007998199,0.00001727996,0.0002668357,0.00001676076,0.001073287,0.9927354,0.0001062512,0.004316454,0.00000609775],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.926055,0.00303373,0.06541205,0.0001620358,0.0001020037,0.0002357895,0.0005418569,0.0005051189,0.003952456],"genre_scores_gemma":[0.947678,0.001754572,0.04130211,0.0001333437,0.00004227665,0.0002172018,0.001076648,0.0001290706,0.007666896],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008461762,"threshold_uncertainty_score":0.002830744,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01223831700445866,"score_gpt":0.3025977896275074,"score_spread":0.2903594726230487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}