{"id":"W2044830228","doi":"10.1042/bj20021318","title":"Cystic fibrosis transmembrane conductance regulator: the NBF1+R (nucleotide-binding fold 1 and regulatory domain) segment acting alone catalyses a Co2+/Mn2+/Mg2+-ATPase activity markedly inhibited by both Cd2+ and the transition-state analogue orthovanadate","year":2003,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; Association Vaincre la Mucoviscidose; Hospital for Sick Children; Philippe Foundation","keywords":"Cystic fibrosis transmembrane conductance regulator; Vanadate; Walker motifs; ATP-binding cassette transporter; Activator (genetics); Cyclic nucleotide-binding domain; Nucleotide; Transporter; ATPase; Transmembrane domain; Biology; Molecular biology; Biochemistry; Chemistry; ATP hydrolysis; Gene; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002147515,0.0006262216,0.000532538,0.000129458,0.0002143506,0.0003279793,0.0003607217,0.0007204277,0.001518739],"category_scores_gemma":[0.0003442452,0.0001176084,0.0002235444,0.0001334017,0.0002897484,0.0002738987,0.0001928614,0.0003373366,0.001800952],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005613444,"about_ca_system_score_gemma":0.0002293063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007978874,"about_ca_topic_score_gemma":0.0006676688,"domain_scores_codex":[0.9998181,0.00002570761,0.00001127821,0.00005867501,0.00005539832,0.00003077212],"domain_scores_gemma":[0.9998752,0.00002249945,0.00003845051,0.00001139977,0.00001703967,0.00003534924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001121554,0.00002275472,0.0003981714,0.0001245257,0.000005716061,0.0001072633,0.00001545326,0.000036685,0.9945378,0.0001809291,0.0003664063,0.004092207],"study_design_scores_gemma":[0.00003770475,0.0002656158,0.01194549,0.00003462168,0.00003121776,0.004599139,0.00002934769,0.001955897,0.9502091,0.0001014368,0.03077552,0.00001495398],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9665364,0.01511505,0.01219253,0.0006248005,0.0002279486,0.0001080501,0.000944866,0.0008429568,0.003407458],"genre_scores_gemma":[0.9734307,0.002513083,0.01261484,0.000203881,0.00006819193,0.00006520014,0.002886503,0.00007127476,0.008146261],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001518739,"threshold_uncertainty_score":0.00508064,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009925695329852881,"score_gpt":0.2521353457466335,"score_spread":0.2422096504167806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}