{"id":"W2044839967","doi":"10.1016/j.bmcl.2010.09.051","title":"Sequential cytotoxicity: A theory examined using a series of 3,5-bis(benzylidene)-1-diethylphosphono-4-oxopiperidines and related phosphonic acids","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Organophosphorus compounds synthesis","field":"Chemistry","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Cytotoxicity; Chemistry; Cytotoxic T cell; Stereochemistry; Cell culture; Apoptosis; Toxicity; DNA fragmentation; Aryl; Fragmentation (computing); Chemical synthesis; In vitro; Biochemistry; Programmed cell death; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006114329,0.0007437946,0.0009196396,0.00008158552,0.0002646398,0.0000786771,0.0007526978,0.0006135172,0.006297585],"category_scores_gemma":[0.0009067925,0.0007396871,0.0002245924,0.0004784522,0.001353024,0.0002651719,0.000360052,0.001062818,0.00001193699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002154336,"about_ca_system_score_gemma":0.0003759869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001869265,"about_ca_topic_score_gemma":0.00001004989,"domain_scores_codex":[0.9964599,0.00004787753,0.001002457,0.0009703788,0.0007197515,0.0007996362],"domain_scores_gemma":[0.9974117,0.0003835657,0.0005879311,0.001089333,0.0001410034,0.0003864879],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003567568,0.00009873429,0.001734306,0.0005529941,0.0002989323,0.0001559911,0.0006658299,0.00000146058,0.9956116,0.00005021121,0.0001051881,0.0003680141],"study_design_scores_gemma":[0.001262276,0.00002828631,0.0004843717,0.0002705144,0.0003499716,0.0009850055,0.0008362207,0.00007213189,0.9942896,0.0001640882,0.0005548465,0.0007026462],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996013,0.001162771,0.00004993226,0.0009671269,0.0005035799,0.0001446835,0.00005761886,0.0002653818,0.0008358618],"genre_scores_gemma":[0.9974234,0.0001132852,0.0009292361,0.0001873915,0.0004725307,0.00001833933,0.00003741858,0.0001559446,0.000662482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006285647,"threshold_uncertainty_score":0.9995054,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009383538204078551,"score_gpt":0.2105553589807276,"score_spread":0.201171820776649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}