{"id":"W2044852418","doi":"10.1021/np2009576","title":"Isolation of Spirastrellolides A and B from a Marine Sponge <i>Epipolasis</i> sp. and Their Cytotoxic Activities","year":2012,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Synthetic Organic Chemistry Methods","field":"Chemistry","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Japan Society for the Promotion of Science; University of British Columbia; University of Cambridge","keywords":"Sponge; Stereochemistry; Cytotoxic T cell; Isolation (microbiology); Biology; China sea; Chemistry; Botany; Biochemistry; Microbiology; In vitro; Oceanography; Geology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007653682,0.0004478419,0.0001436163,0.000346015,0.0001422888,0.0001958169,0.0001179144,0.0001441802,0.0006707154],"category_scores_gemma":[0.0001169024,0.00009698085,0.0002085199,0.0002515357,0.0001576165,0.0001651916,0.0002478855,0.0002170108,0.0002233448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001284302,"about_ca_system_score_gemma":0.0002336974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001117878,"about_ca_topic_score_gemma":0.002082972,"domain_scores_codex":[0.9999381,0.000009657698,0.000009261908,0.000009750494,0.00002271561,0.0000104088],"domain_scores_gemma":[0.9999202,0.000009104006,0.00001763112,0.000008038947,0.00002004098,0.0000249375],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006249749,0.000005286471,0.0005898246,0.0000496434,0.000008694024,0.000135859,0.0000160718,0.00003987316,0.9971968,0.0000192223,0.0000117718,0.00186443],"study_design_scores_gemma":[0.00003148508,0.0007739392,0.03837425,0.00002356714,0.00005899716,0.0009620245,0.0001639321,0.0001793347,0.9553564,0.00006325971,0.003995924,0.00001696655],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952378,0.001977291,0.0007815432,0.00004220943,0.000008394655,0.0000203961,0.0003257164,0.00001065764,0.001595795],"genre_scores_gemma":[0.9935133,0.002011909,0.001764653,0.00004086783,0.00000814507,0.00001793354,0.001023918,0.000007274435,0.00161203],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001117878,"threshold_uncertainty_score":0.002243698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0130750511303434,"score_gpt":0.240670537093707,"score_spread":0.2275954859633636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}