{"id":"W2044892619","doi":"10.1074/jbc.c500244200","title":"Focally Elevated Creatine Detected in Amyloid Precursor Protein (APP) Transgenic Mice and Alzheimer Disease Brain Tissue","year":2005,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Muscle metabolism and nutrition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto; University of Manitoba","funders":"","keywords":"Genetically modified mouse; Amyloid precursor protein; Creatine; Amyloid (mycology); Transgene; Brain tissue; Pathology; Amyloid β; β amyloid; Disease; Neuroscience; Medicine; Alzheimer's disease; Biology; Endocrinology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003270869,0.000851205,0.0004847511,0.00165532,0.0004528143,0.0005734239,0.0004022455,0.00124658,0.002066635],"category_scores_gemma":[0.0002689035,0.0005814914,0.000579746,0.0005450409,0.0006557892,0.0004267893,0.0004873786,0.001453614,0.000560895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004371025,"about_ca_system_score_gemma":0.0002486717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001270953,"about_ca_topic_score_gemma":0.001887759,"domain_scores_codex":[0.9994959,0.00004031759,0.00006646822,0.0001706789,0.0001087727,0.0001178287],"domain_scores_gemma":[0.9993454,0.00005554666,0.0003124904,0.0000377961,0.00006399799,0.000184881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002117767,0.00007425015,0.0003349585,0.00002773496,0.00001174967,0.0003748222,0.00005854951,0.00001841366,0.9984165,0.00007556838,0.00003332502,0.0003623342],"study_design_scores_gemma":[0.0001321282,0.002081251,0.08429351,0.00006186589,0.0001494532,0.008252531,0.000305963,0.0009597036,0.899627,0.0003703713,0.003717791,0.0000483494],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929471,0.00145259,0.002579532,0.0001815255,0.00005500418,0.0000795506,0.001053584,0.0001635473,0.001487483],"genre_scores_gemma":[0.9829068,0.001708339,0.005984104,0.000201602,0.000027755,0.0002309358,0.001670497,0.0001242534,0.007145667],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002066635,"threshold_uncertainty_score":0.006913602,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01262371607297146,"score_gpt":0.2566145313764084,"score_spread":0.243990815303437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}