{"id":"W2044893269","doi":"10.1097/fpc.0b013e3283369347","title":"Chrna4 A529 knock-in mice exhibit altered nicotine sensitivity","year":2010,"lang":"en","type":"article","venue":"Pharmacogenetics and Genomics","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Cancer Institute; National Institute on Drug Abuse; National Institute on Alcohol Abuse and Alcoholism","keywords":"Nicotine; Gene knockin; Nicotinic agonist; Biology; Nicotinic acetylcholine receptor; Acetylcholine receptor; Genetics; Conditioned place preference; Endocrinology; Pharmacology; Receptor; Internal medicine; Gene; Medicine; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003832704,0.001277101,0.0006819417,0.001302261,0.0005149475,0.000815493,0.0006885306,0.001676538,0.008729075],"category_scores_gemma":[0.0004006126,0.0006815565,0.0007476898,0.0004236424,0.001019281,0.0004304847,0.0005003824,0.001776843,0.001873605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005292376,"about_ca_system_score_gemma":0.0003354203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001516699,"about_ca_topic_score_gemma":0.00228666,"domain_scores_codex":[0.9990674,0.0000953602,0.0001550888,0.0003261672,0.0001947992,0.000161208],"domain_scores_gemma":[0.9986695,0.0001780327,0.0005339355,0.0001129161,0.00007139101,0.0004341326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003722711,0.00008573217,0.0002976919,0.00003463661,0.0000233698,0.0002793974,0.00002910216,0.00008746754,0.9978796,0.0001379126,0.00008701716,0.0006858155],"study_design_scores_gemma":[0.000338153,0.001521364,0.0274089,0.00008752916,0.0002060531,0.003876556,0.0002493597,0.002988326,0.9579119,0.0004378454,0.004901303,0.00007282879],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894357,0.0006693601,0.004418594,0.0004168816,0.0001923265,0.00006034493,0.0023947,0.0004849954,0.001927058],"genre_scores_gemma":[0.9795769,0.0008167021,0.004599423,0.0003813334,0.0000660773,0.0001632713,0.001947421,0.0004508944,0.01199785],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008729075,"threshold_uncertainty_score":0.02920163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0074675665202373,"score_gpt":0.2658720760944936,"score_spread":0.2584045095742564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}