{"id":"W2044898071","doi":"10.1097/ftd.0b013e31815c12ca","title":"Achievement of Target Cyclosporine Concentrations as a Predictor of Severe Acute Graft Versus Host Disease in Children Undergoing Hematopoietic Stem Cell Transplantation and Receiving Cyclosporine and Methotrexate Prophylaxis","year":2007,"lang":"en","type":"article","venue":"Therapeutic Drug Monitoring","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Izaak Walton Killam Health Centre; Institute for Clinical Evaluative Sciences; University of Toronto; SickKids Foundation; Dalhousie University; Hospital for Sick Children","funders":"Novartis Pharmaceuticals Canada","keywords":"Medicine; Methotrexate; Hematopoietic stem cell transplantation; Univariate analysis; Folinic acid; Internal medicine; Odds ratio; Graft-versus-host disease; Transplantation; Gastroenterology; Surgery; Chemotherapy; Multivariate analysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004054781,0.0002525419,0.0002859584,0.0005089251,0.0002465262,0.0004174114,0.0002097995,0.0003404084,0.0005466653],"category_scores_gemma":[0.002636212,0.0002189256,0.0002705377,0.000566483,0.000289697,0.0003898705,0.0002841807,0.0005739414,0.0001024555],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003133487,"about_ca_system_score_gemma":0.000520146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002439526,"about_ca_topic_score_gemma":0.002880009,"domain_scores_codex":[0.9996682,0.00008786807,0.00004398063,0.00004784677,0.00007952662,0.00007261686],"domain_scores_gemma":[0.9972057,0.0007560637,0.001418853,0.00005887784,0.0001268387,0.0004335908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00007355905,0.000009846889,0.9989113,0.00000279442,0.000007346815,0.0001028004,0.00001776891,0.00005549585,0.0001810238,0.000003352808,0.00002046971,0.0006142471],"study_design_scores_gemma":[0.000009740361,0.0002306001,0.9976357,0.000003590298,0.00002183141,0.001372226,0.00009101455,0.0003489042,0.000198632,0.000007614387,0.00007735052,0.000002818809],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9997917,0.00009459211,0.00002846448,0.00001128903,0.000001080562,0.000001268559,0.00002372334,0.000001469727,0.00004649347],"genre_scores_gemma":[0.9997651,0.00006042193,0.00007295835,0.000006374288,0.000005484456,0.000002274752,0.00007055858,0.000001092466,0.00001570877],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002439526,"threshold_uncertainty_score":0.004850626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01214396684558048,"score_gpt":0.2683119188611172,"score_spread":0.2561679520155367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}