{"id":"W2044898071","doi":"10.1097/ftd.0b013e31815c12ca","title":"Achievement of Target Cyclosporine Concentrations as a Predictor of Severe Acute Graft Versus Host Disease in Children Undergoing Hematopoietic Stem Cell Transplantation and Receiving Cyclosporine and Methotrexate Prophylaxis","year":2007,"lang":"en","type":"article","venue":"Therapeutic Drug Monitoring","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Izaak Walton Killam Health Centre; Institute for Clinical Evaluative Sciences; University of Toronto; SickKids Foundation; Dalhousie University; Hospital for Sick Children","funders":"Novartis Pharmaceuticals Canada","keywords":"Medicine; Methotrexate; Hematopoietic stem cell transplantation; Univariate analysis; Folinic acid; Internal medicine; Odds ratio; Graft-versus-host disease; Transplantation; Gastroenterology; Surgery; Chemotherapy; Multivariate analysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005535963,0.0002652238,0.0004624499,0.0002101473,0.00006620356,0.00001344272,0.00007938608,0.00007930437,0.000007644967],"category_scores_gemma":[0.000009107917,0.0002569989,0.00006281049,0.0003053127,0.0001073458,0.0001583304,0.00001963039,0.000201174,7.305915e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008570905,"about_ca_system_score_gemma":0.00009708834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001258241,"about_ca_topic_score_gemma":0.00001219,"domain_scores_codex":[0.9980717,0.00008699823,0.0007062432,0.0003633171,0.0004411116,0.0003305741],"domain_scores_gemma":[0.998815,0.0003950236,0.0002574491,0.0002361492,0.00007728583,0.0002191079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001904487,0.0002294186,0.9296254,0.001672941,0.0002584158,0.00005461457,0.007658631,0.00007714551,0.05728236,0.000113854,1.50305e-7,0.001122608],"study_design_scores_gemma":[0.005417458,0.0003169633,0.8224421,0.00102104,0.000612667,0.00004832574,0.001190493,0.00005518251,0.1686081,0.00008920371,0.000001523679,0.00019691],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959177,0.001457151,0.001087166,0.0001066066,0.0002061237,0.001025337,0.00004007531,0.00004425707,0.0001155795],"genre_scores_gemma":[0.9954144,0.002347598,0.002006024,0.000009192979,0.00007104372,0.0000213735,0.0000390064,0.00004030044,0.0000510399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1113258,"threshold_uncertainty_score":0.9999882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01214396684558048,"score_gpt":0.2683119188611172,"score_spread":0.2561679520155367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}