{"id":"W2044910404","doi":"10.1016/s0960-894x(00)00636-3","title":"Potent and selective bicyclic lactam inhibitors of thrombin. Part 4: transition state inhibitors","year":2001,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical synthesis and pharmacological studies","field":"Chemistry","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"BioPhage Pharma (Canada)","funders":"","keywords":"Bicyclic molecule; Chemistry; Thrombin; Cyclohexylamine; In vivo; Lactam; Discovery and development of direct thrombin inhibitors; Selectivity; Stereochemistry; Chemical synthesis; In vitro; Pharmacology; Biochemistry; Organic chemistry; Platelet; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001677376,0.0003357743,0.0004736993,0.00002141703,0.0001225341,0.00001567066,0.0001627613,0.0001648135,0.001126746],"category_scores_gemma":[0.0001047308,0.0002777372,0.0001305446,0.0002388572,0.0004282726,0.00006420168,0.00007116934,0.0003859891,0.00000613148],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001583915,"about_ca_system_score_gemma":0.00002611724,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007945933,"about_ca_topic_score_gemma":0.000001968569,"domain_scores_codex":[0.9981,0.00002313645,0.0005205533,0.0004899249,0.0004282561,0.0004381624],"domain_scores_gemma":[0.9991429,0.0001722804,0.0002136,0.0001686539,0.00005900629,0.0002434869],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001282349,0.0001569783,0.001986834,0.0002435378,0.0001361603,0.00003980595,0.0003669176,0.000001276777,0.9893246,4.148457e-7,0.00469466,0.002920581],"study_design_scores_gemma":[0.0008820485,0.0000261704,0.0008592018,0.0001880556,0.0001174573,0.00006908314,0.0003178232,0.000009418384,0.9931316,0.00004700968,0.004051416,0.0003007328],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926346,0.000868643,0.00001509181,0.00475631,0.00008429853,0.0000844971,0.00003055668,0.0000856667,0.00144032],"genre_scores_gemma":[0.9977809,0.0008136645,0.00001835281,0.0006137185,0.0006258452,0.00001733207,0.00002728293,0.00002761801,0.00007529415],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005146276,"threshold_uncertainty_score":0.9999675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01177336084793842,"score_gpt":0.2210923440100558,"score_spread":0.2093189831621173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}