{"id":"W2044930949","doi":"10.1021/bi060009z","title":"The Paired Domain of Pax3 Contains a Putative Homeodomain Interaction Pocket Defined by Cysteine Scanning Mutagenesis","year":2006,"lang":"en","type":"article","venue":"Biochemistry","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Mutant; Cysteine; DNA; Mutagenesis; PAX3; HMG-box; Binding site; DNA-binding domain; Homeobox; Site-directed mutagenesis; Binding domain; Molecular biology; Chemistry; DNA binding site; Transcription factor; Biology; DNA-binding protein; Gene; Biochemistry; Gene expression; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001550258,0.0004030422,0.0002383364,0.0001679012,0.0001912459,0.0001502878,0.0003071378,0.0002303767,0.001522173],"category_scores_gemma":[0.0001239136,0.0001452265,0.0002958798,0.0001888754,0.0003057151,0.000143942,0.0002427,0.0004790234,0.0004618257],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004631456,"about_ca_system_score_gemma":0.0002326764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000772154,"about_ca_topic_score_gemma":0.001178404,"domain_scores_codex":[0.999896,0.00002465375,0.0000092964,0.00001900706,0.00003529793,0.00001565143],"domain_scores_gemma":[0.9999126,0.00002122198,0.00002392217,0.00001102684,0.00001096534,0.00002014216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001836243,0.00002034242,0.0002127848,0.00002834386,0.000005963783,0.00009887291,0.00001102773,0.000152338,0.9977202,0.00015102,0.00003052145,0.001384957],"study_design_scores_gemma":[0.00005156699,0.0002867945,0.004787301,0.000008189711,0.00002514476,0.0007415374,0.00002526316,0.001210781,0.98931,0.00008566394,0.003456076,0.0000117285],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909583,0.0004201256,0.006591599,0.00006468083,0.00002241992,0.00008075048,0.0005006469,0.00009406931,0.001267334],"genre_scores_gemma":[0.9930982,0.0001849862,0.004706415,0.00004000252,0.000005415715,0.00003331878,0.0008322854,0.0000182737,0.001081153],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001522173,"threshold_uncertainty_score":0.005092204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006634379604697527,"score_gpt":0.2441398680891976,"score_spread":0.2375054884845001,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}