{"id":"W2044934700","doi":"10.1158/1538-7445.am2014-5028","title":"Abstract 5028: Metronomic cyclophosphamide enhances the immunogenicity and anti-tumor activity of a DepoVax based vaccine and may be further enhanced with inhibitors of CTLA-4 or PD-1","year":2014,"lang":"en","type":"article","venue":"Cancer Research","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen Elizabeth II Health Sciences Centre; Sunnybrook Health Science Centre; Health Sciences Centre; Immunovaccine (Canada)","funders":"","keywords":"ELISPOT; Cytotoxic T cell; Immune system; Immunogenicity; Immunology; Cancer vaccine; CD8; Cyclophosphamide; Antigen; Granzyme B; Cancer research; Medicine; Immunotherapy; Biology; Internal medicine; Chemotherapy; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007901588,0.0003737306,0.0003007009,0.000203496,0.00007164528,0.0001904972,0.0001514524,0.0002125271,0.002811499],"category_scores_gemma":[0.00008880773,0.0001011516,0.0001645965,0.0001162049,0.0001376365,0.0001521907,0.0001198487,0.0006539776,0.0004196299],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001798302,"about_ca_system_score_gemma":0.0002635005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003286034,"about_ca_topic_score_gemma":0.0005284394,"domain_scores_codex":[0.9999214,0.00001436819,0.000005355192,0.0000132234,0.00001854607,0.00002698908],"domain_scores_gemma":[0.9999419,0.00001030547,0.00001297431,0.000005955817,0.000005268616,0.00002352123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001216433,0.0003323352,0.0001687917,0.00006281082,0.00001419462,0.0000467856,0.00000615121,0.0001792768,0.9923235,0.00009004274,0.0002888091,0.005270923],"study_design_scores_gemma":[0.0005429654,0.01187304,0.005404998,0.00001397737,0.00004722531,0.0004406782,0.000009309614,0.001590221,0.9762951,0.00005075193,0.003725764,0.000005924388],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955353,0.0009418281,0.00088254,0.0001204255,0.00006464591,0.00005603715,0.0003599105,0.00009924787,0.001940134],"genre_scores_gemma":[0.9950687,0.0004001197,0.001062411,0.00005716399,0.00003017725,0.00004662484,0.0005600402,0.00001596825,0.002758803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002811499,"threshold_uncertainty_score":0.009405375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02279484029533429,"score_gpt":0.3172420910421991,"score_spread":0.2944472507468648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}