{"id":"W2044939539","doi":"10.3389/fncel.2013.00050","title":"The essential roles of protein–protein interaction in sigma-1 receptor functions","year":2013,"lang":"en","type":"article","venue":"Frontiers in Cellular Neuroscience","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Neuroscience; Receptor; Sigma; Neurophysiology; Protein expression; Cell biology; Biology; Physics; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002740739,0.0001080795,0.0001090069,0.00006220534,0.00009232845,0.00003673656,0.0002996151,0.00008162836,0.00002295355],"category_scores_gemma":[0.0002319828,0.00008125566,0.00005331212,0.0002441263,0.000169841,0.00001805135,0.0001081843,0.000162922,0.000006086197],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002129443,"about_ca_system_score_gemma":0.00003673753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003173712,"about_ca_topic_score_gemma":0.00001457229,"domain_scores_codex":[0.9988934,0.0001515776,0.0002128959,0.00032441,0.0001519412,0.0002657906],"domain_scores_gemma":[0.9996209,0.00001139785,0.00009112263,0.0001865576,0.00003398484,0.00005607327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004770236,0.00006992596,0.0004120558,0.000006847468,0.00000139401,0.000001193749,0.00001162907,0.0002044307,0.9939548,0.00002697885,0.0008790446,0.004383941],"study_design_scores_gemma":[0.0002271669,0.0002194151,0.0004891134,0.00001692845,0.000001629985,6.246708e-7,0.0001073666,0.002675678,0.9870879,0.0001961308,0.008883569,0.0000944715],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9813305,0.0002674314,0.01628401,0.0001812773,0.001169337,0.0006137033,0.000002559651,0.000006430306,0.000144749],"genre_scores_gemma":[0.9983763,0.00006560162,0.0005808062,0.00006122234,0.00005684584,0.0001720733,0.000005257899,0.000008447817,0.0006734846],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01704576,"threshold_uncertainty_score":0.331351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00751723044177431,"score_gpt":0.2318253157865181,"score_spread":0.2243080853447438,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}