{"id":"W2044939869","doi":"10.1038/sj.tpj.6500210","title":"Influence of CYP2C9 genotypes on the formation of a hepatotoxic metabolite of valproic acid in human liver microsomes","year":2003,"lang":"en","type":"article","venue":"The Pharmacogenomics Journal","topic":"Pharmacological Effects and Toxicity Studies","field":"Medicine","cited_by":99,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"CYP2C9; Metabolite; Microsome; Biotransformation; Cytochrome P450; Valproic Acid; Genotype; Chemistry; Biochemistry; Pharmacology; Pharmacogenetics; Biology; Metabolism; In vitro; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00123072,0.0001300305,0.0003769613,0.0001200758,0.0001197175,0.000006089792,0.0002025197,0.00003327573,0.00004915489],"category_scores_gemma":[0.0001462973,0.00006610791,0.0001492927,0.0002051806,0.0002150615,0.00007790597,0.00004511265,0.0003758005,0.000002747135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005602788,"about_ca_system_score_gemma":0.0000529024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001206906,"about_ca_topic_score_gemma":0.000001662088,"domain_scores_codex":[0.9986886,0.0002843658,0.0005360848,0.00008272516,0.0002167537,0.0001914343],"domain_scores_gemma":[0.998993,0.0002169225,0.0004579296,0.0001298545,0.0001485669,0.00005376023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002568165,0.0002318425,0.001768028,0.00008802859,0.00016896,0.000008938031,0.001223975,0.001100714,0.9938881,0.0007338665,0.00004013602,0.0004905461],"study_design_scores_gemma":[0.001477641,0.0002557211,0.01155412,0.00007285217,0.00022562,0.0001017958,0.0001012157,0.0003569498,0.9846705,0.0008188448,0.0002995501,0.00006515808],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953281,0.003544823,0.00003071765,0.0003324395,0.00004109155,0.000421612,0.00001544662,0.000003465417,0.0002822882],"genre_scores_gemma":[0.9963294,0.002988306,0.00005975933,0.0005496081,0.0000413212,0.000007684201,5.872603e-7,0.000009034246,0.00001426607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009786094,"threshold_uncertainty_score":0.2695802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03695985506617777,"score_gpt":0.3124122668086537,"score_spread":0.2754524117424759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}