{"id":"W2044942738","doi":"10.1073/pnas.092160899","title":"CFTR is a pattern recognition molecule that extracts <i>Pseudomonas aeruginosa</i> LPS from the outer membrane into epithelial cells and activates NF-κB translocation","year":2002,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":156,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; Canadian Lung Association; National Institutes of Health; Brigham and Women's Hospital","keywords":"Internalization; Endocytic cycle; Cell biology; Endocytosis; Innate immune system; Biology; Receptor; Immune system; Immunology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007009483,0.0001324603,0.0001945317,0.0001061055,0.0002172482,0.00005231175,0.0004058607,0.00008415584,0.00009694685],"category_scores_gemma":[0.0004252075,0.00007644991,0.00007378922,0.0004148289,0.0008872671,0.000620637,0.00007164147,0.0002494006,0.000007229218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003414576,"about_ca_system_score_gemma":0.00002200537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007477563,"about_ca_topic_score_gemma":7.355268e-7,"domain_scores_codex":[0.9976743,0.00001568912,0.000291013,0.0003256819,0.001501626,0.0001916599],"domain_scores_gemma":[0.9989064,0.0004603566,0.0002813258,0.0000181363,0.0002654913,0.00006824371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005589066,0.00007080397,0.001333746,0.00008367711,0.00002486982,3.680534e-8,0.001458786,0.000002871674,0.976153,0.00004553706,0.0007285291,0.02004223],"study_design_scores_gemma":[0.0005030034,0.00008276359,0.01196042,0.0002960138,0.00003004277,0.00001270661,0.0003696084,0.001592446,0.9772346,0.007477835,0.000354519,0.00008603621],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9721402,0.0005698513,0.00001816297,0.02603757,0.00002323582,0.0004200091,0.00009140787,0.00001359059,0.0006859562],"genre_scores_gemma":[0.995732,0.000563571,0.002237007,0.001242074,0.0001263234,0.00002372214,0.000001285369,0.000007540543,0.00006647843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02479549,"threshold_uncertainty_score":0.3269173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.051845963364508,"score_gpt":0.2988700860656466,"score_spread":0.2470241227011386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}