{"id":"W2045019620","doi":"10.1074/jbc.m114.607481","title":"Structural and Functional Characterization of a Ketosteroid Transcriptional Regulator of Mycobacterium tuberculosis","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Steroid Chemistry and Biochemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Toronto","funders":"Argonne National Laboratory; Biological and Environmental Research; National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health; Michael Smith Health Research BC; U.S. Department of Energy","keywords":"Isothermal titration calorimetry; Chemistry; Stereochemistry; Dimer; Ligand (biochemistry); Repressor; Biochemistry; Gene; Gene expression; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002005584,0.000171627,0.0003158328,0.00001623064,0.00002965911,0.000008781745,0.0001437159,0.0003136669,0.00009705833],"category_scores_gemma":[0.0001355219,0.0001322528,0.0001857193,0.00005753904,0.0002092852,0.000008764313,0.00005646523,0.0001361186,1.508558e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001001167,"about_ca_system_score_gemma":0.00004124647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":3.396354e-7,"about_ca_topic_score_gemma":4.238051e-8,"domain_scores_codex":[0.9988585,0.00003431585,0.0005776018,0.0002070215,0.0001839388,0.0001386994],"domain_scores_gemma":[0.9989158,0.00002303453,0.0005312775,0.0001604603,0.0002634159,0.0001060059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004908709,0.00005228108,0.009960995,0.0001848571,0.00007909995,6.753269e-7,0.00001015843,0.000003439692,0.9888256,0.000004916962,0.00002760998,0.0003594914],"study_design_scores_gemma":[0.0006386074,0.0002355191,0.07159417,0.00004873877,0.00003137416,0.0002316745,0.00002369368,0.00001620533,0.9264311,0.00004029517,0.0005822665,0.0001263891],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990971,0.0002587506,0.0002588503,0.00007728853,0.00008302549,0.00003243478,0.00006749135,0.000002950468,0.0001220927],"genre_scores_gemma":[0.9988188,0.0001246962,0.0001965216,0.00004302543,0.00052403,0.000001553163,0.000195458,0.000007978429,0.0000879751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06239454,"threshold_uncertainty_score":0.5393113,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0114143646431878,"score_gpt":0.2062588321781975,"score_spread":0.1948444675350097,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}