{"id":"W2045027538","doi":"10.1158/0008-5472.can-04-2940","title":"Inhibition of Integrin-Linked Kinase by a Selective Small Molecule Inhibitor, QLT0254, Inhibits the PI3K/PKB/mTOR, Stat3, and FKHR Pathways and Tumor Growth, and Enhances Gemcitabine-Induced Apoptosis in Human Orthotopic Primary Pancreatic Cancer Xenografts","year":2005,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":133,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Protein kinase B; GSK-3; Integrin-linked kinase; PI3K/AKT/mTOR pathway; Kinase; P70-S6 Kinase 1; Cancer research; FOXO1; GSK3B; Ribosomal s6 kinase; Chemistry; Phosphorylation; Signal transduction; Biology; Protein kinase A; Cell biology; Cyclin-dependent kinase 2","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008964941,0.0003827394,0.0003329314,0.0002214647,0.0001350754,0.0002330047,0.0002255812,0.0002211371,0.001258826],"category_scores_gemma":[0.000102765,0.0001512051,0.0002922865,0.000243994,0.0001592647,0.000173125,0.0001067926,0.0005769765,0.0004295007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000398797,"about_ca_system_score_gemma":0.0002610417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006645164,"about_ca_topic_score_gemma":0.001949308,"domain_scores_codex":[0.9999126,0.00001420522,0.00001004375,0.00001421595,0.00001960584,0.00002939701],"domain_scores_gemma":[0.999966,0.000004970709,0.00001136091,0.000004460289,0.000003112934,0.00001006445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004046999,0.0002028704,0.000249985,0.00005488452,0.00001664664,0.00004632286,0.00001219112,0.0002795132,0.9924713,0.00007949975,0.0003247122,0.005857217],"study_design_scores_gemma":[0.0004608353,0.004197342,0.007022751,0.000009818535,0.00005636845,0.0005349268,0.00002697661,0.002577879,0.9814236,0.00005065037,0.003627882,0.0000109616],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941963,0.001626278,0.001264502,0.0001574766,0.00004076968,0.00006523505,0.0004226266,0.0001715158,0.002055366],"genre_scores_gemma":[0.9946608,0.001281837,0.001214122,0.00007256842,0.0000113179,0.00009398945,0.0008415568,0.00001500768,0.001808848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001258826,"threshold_uncertainty_score":0.004211187,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04145909334888549,"score_gpt":0.336223627554926,"score_spread":0.2947645342060405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}