{"id":"W2045027538","doi":"10.1158/0008-5472.can-04-2940","title":"Inhibition of Integrin-Linked Kinase by a Selective Small Molecule Inhibitor, QLT0254, Inhibits the PI3K/PKB/mTOR, Stat3, and FKHR Pathways and Tumor Growth, and Enhances Gemcitabine-Induced Apoptosis in Human Orthotopic Primary Pancreatic Cancer Xenografts","year":2005,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":133,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Protein kinase B; GSK-3; Integrin-linked kinase; PI3K/AKT/mTOR pathway; Kinase; P70-S6 Kinase 1; Cancer research; FOXO1; GSK3B; Ribosomal s6 kinase; Chemistry; Phosphorylation; Signal transduction; Biology; Protein kinase A; Cell biology; Cyclin-dependent kinase 2","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001190857,0.0003644627,0.0006734686,0.0005441423,0.0003172792,0.00009840125,0.0001768999,0.0001887064,0.00006551939],"category_scores_gemma":[0.0003839463,0.0002843069,0.00006498554,0.001202964,0.0007925603,0.0002047455,0.0004181616,0.001379835,0.000002200604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000554649,"about_ca_system_score_gemma":0.0005912753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005746559,"about_ca_topic_score_gemma":0.002685802,"domain_scores_codex":[0.9959329,0.0005996742,0.0006340003,0.000892273,0.001046472,0.0008946348],"domain_scores_gemma":[0.9979858,0.000443471,0.0001514441,0.0003754105,0.0006400157,0.0004038936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000476031,0.0002671159,0.01230983,0.0009064785,0.0000665867,0.00003555914,0.002372315,7.96014e-7,0.9760482,0.00005915826,0.000426657,0.007031215],"study_design_scores_gemma":[0.003368411,0.0009911775,0.02409322,0.001113757,0.00004940504,0.00001754397,0.0009171643,0.00006646735,0.9688109,0.0001033806,0.0001938174,0.000274811],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877717,0.007668114,0.000008048261,0.001710165,0.00003464168,0.002189907,0.00004928759,0.00003369692,0.0005344459],"genre_scores_gemma":[0.9927881,0.005176077,0.0001098496,0.0002591947,0.0001856826,0.001126778,0.00003497033,0.00006785987,0.0002514622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01178338,"threshold_uncertainty_score":0.9999609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04145909334888549,"score_gpt":0.336223627554926,"score_spread":0.2947645342060405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}