{"id":"W2045062204","doi":"10.1126/science.1232685","title":"Influence of HLA-C Expression Level on HIV Control","year":2013,"lang":"en","type":"article","venue":"Science","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":382,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver; Simon Fraser University","funders":"National Institute on Drug Abuse; National Institute of Mental Health; National Heart, Lung, and Blood Institute; National Health and Medical Research Council; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; Medical Research Council; Center for AIDS Research, University of Washington; National Center for Research Resources; China Scholarship Council; National Cancer Institute; International AIDS Society; British Heart Foundation; Wellcome Trust; Deutsches Krebsforschungszentrum; Massachusetts General Hospital; Bill and Melinda Gates Foundation; National Science Foundation; National Institutes of Health; U.S. Department of Health and Human Services; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; U.S. Department of Defense","keywords":"Human leukocyte antigen; HLA-C; Cytotoxic T cell; Immunology; HLA-B Antigens; Allele; Biology; Disease; Genetics; Antigen; Medicine; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003032164,0.0001232137,0.0002077486,0.0002027639,0.0001482338,0.0003995163,0.00009878448,0.0001755724,0.001368898],"category_scores_gemma":[0.0008819052,0.00005274495,0.00009471174,0.0002435027,0.000233995,0.0001035028,0.0001989275,0.0002349297,0.0001318885],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001722048,"about_ca_system_score_gemma":0.0001092489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007063628,"about_ca_topic_score_gemma":0.0005288384,"domain_scores_codex":[0.9995862,0.0001892252,0.00002150502,0.00007173026,0.00004679107,0.00008466742],"domain_scores_gemma":[0.999487,0.0002377047,0.0000866941,0.00006175302,0.0000388158,0.00008787125],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003353361,0.0001979954,0.3677307,0.00005050691,0.0001400918,0.0006684493,0.0002607057,0.0005532143,0.6077917,0.0005043584,0.0001776216,0.0185712],"study_design_scores_gemma":[0.00003326354,0.001049576,0.9337226,0.00001911631,0.0001219315,0.001368064,0.0002260251,0.001474682,0.06027339,0.0002126935,0.001481663,0.00001708077],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992443,0.0001730073,0.00007648519,0.00001142903,0.00000216104,0.000001935056,0.00003823912,0.000001768762,0.000450767],"genre_scores_gemma":[0.9997767,0.00004201862,0.0000493839,0.000009100199,0.000001745957,0.0000015253,0.00002582749,0.000001627243,0.00009217965],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001368898,"threshold_uncertainty_score":0.004579484,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0122881814823819,"score_gpt":0.2347867488245231,"score_spread":0.2224985673421412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}