{"id":"W2045062204","doi":"10.1126/science.1232685","title":"Influence of HLA-C Expression Level on HIV Control","year":2013,"lang":"en","type":"article","venue":"Science","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":382,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver; Simon Fraser University","funders":"National Institute on Drug Abuse; National Institute of Mental Health; National Heart, Lung, and Blood Institute; National Health and Medical Research Council; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; Medical Research Council; Center for AIDS Research, University of Washington; National Center for Research Resources; China Scholarship Council; National Cancer Institute; International AIDS Society; British Heart Foundation; Wellcome Trust; Deutsches Krebsforschungszentrum; Massachusetts General Hospital; Bill and Melinda Gates Foundation; National Science Foundation; National Institutes of Health; U.S. Department of Health and Human Services; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; U.S. Department of Defense","keywords":"Human leukocyte antigen; HLA-C; Cytotoxic T cell; Immunology; HLA-B Antigens; Allele; Biology; Disease; Genetics; Antigen; Medicine; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0001689434,0.00005786081,0.00008070698,0.00009684583,0.0001430363,0.00001096751,0.0002053468,0.00004743289,0.001096517],"category_scores_gemma":[0.0001842225,0.00004293564,0.00002372791,0.0001394642,0.0003890843,0.0003364159,0.00002916727,0.000113182,0.003256185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000204143,"about_ca_system_score_gemma":0.00004077196,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004005124,"about_ca_topic_score_gemma":3.258766e-7,"domain_scores_codex":[0.9994619,0.00003601301,0.000136547,0.0001591748,0.00004505566,0.0001613122],"domain_scores_gemma":[0.9995088,0.00006026463,0.00007926382,0.0001891128,0.0001501413,0.00001243174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003050829,0.00003050239,0.000726466,0.000001610507,0.000001985525,6.883027e-8,0.00007049829,0.0001639617,0.9945423,0.0001870579,0.003480345,0.0007646721],"study_design_scores_gemma":[0.0004106257,0.0001027453,0.08628018,0.00003031876,0.000001638753,0.000004509526,0.00008047743,0.00002694799,0.9058402,0.00004493789,0.007126741,0.00005068377],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954532,0.0000627917,0.0002980682,0.0001701815,0.0007739536,0.0001176566,0.000001511128,0.0000206225,0.003102062],"genre_scores_gemma":[0.9922656,0.00000427322,0.00002767311,0.0003529728,0.000005454907,0.0000106523,0.000001868731,0.000002221639,0.007329275],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08870213,"threshold_uncertainty_score":0.9998166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0122881814823819,"score_gpt":0.2347867488245231,"score_spread":0.2224985673421412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}