{"id":"W2045091720","doi":"10.1016/j.bbrc.2010.03.045","title":"Catalytic properties of thimet oligopeptidase H600A mutant","year":2010,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Fonds de Recherche du Québec - Santé; Graduate Fellowships for Science, Technology, Engineering, and Mathematics Diversity","keywords":"Chemistry; Oligopeptidase; Substrate (aquarium); Mutant; Stereochemistry; Active site; Hydrolase; Residue (chemistry); Mutagenesis; Catalysis; Hydrolysis; Oxyanion hole; Biochemistry; Enzyme; Biophysics; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001219668,0.000336715,0.0002639893,0.0001309384,0.000123841,0.0002952128,0.0003561646,0.0003226342,0.001333532],"category_scores_gemma":[0.0003274382,0.0001269797,0.0002081556,0.0002783734,0.0001922356,0.000159692,0.0001341562,0.0005546974,0.0004821538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003371369,"about_ca_system_score_gemma":0.0002321034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003699253,"about_ca_topic_score_gemma":0.001224745,"domain_scores_codex":[0.9998366,0.00001713385,0.00002592257,0.00003005703,0.00005991526,0.00003037765],"domain_scores_gemma":[0.9998028,0.00004662929,0.00003411455,0.00002254666,0.00004516014,0.00004877042],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001688994,0.00003528759,0.0002091096,0.0000149774,0.000006330748,0.00006347721,0.00001762858,0.00008274844,0.9986892,0.00007876335,0.0000427815,0.0005907717],"study_design_scores_gemma":[0.0000126307,0.0001010237,0.003160383,0.000003278991,0.000009308625,0.0002368561,0.00003984668,0.001469155,0.9941757,0.00002995642,0.0007525326,0.000009290843],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973516,0.0002587875,0.0009175104,0.00006154996,0.00002938565,0.00000781277,0.0006399009,0.00002930503,0.0007041461],"genre_scores_gemma":[0.9951674,0.0001772041,0.0008081275,0.00002185821,0.000004922943,0.000009360903,0.00116144,0.00002676806,0.002622974],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003699253,"threshold_uncertainty_score":0.007355452,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09998876824884317,"score_gpt":0.3788265730385479,"score_spread":0.2788378047897047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}