{"id":"W2045103043","doi":"10.1038/sj.leu.2403335","title":"Growth autonomy and lineage switching in BCR-ABL-transduced human cord blood cells depend on different functional domains of BCR-ABL","year":2004,"lang":"en","type":"article","venue":"Leukemia","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Haematopoiesis; Biology; Cancer research; Imatinib mesylate; K562 cells; Tyrosine kinase; ABL; Stem cell; Growth factor; Cell biology; Imatinib; Leukemia; Immunology; Signal transduction; Myeloid leukemia; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001998436,0.000161104,0.0002082239,0.0002998447,0.0002329501,0.0004808217,0.0001780389,0.000225595,0.002393537],"category_scores_gemma":[0.0002384226,0.0001487363,0.0001863727,0.0002117335,0.0001948927,0.0002482985,0.0002819768,0.0006827075,0.0004974256],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002800131,"about_ca_system_score_gemma":0.0002189236,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001183546,"about_ca_topic_score_gemma":0.00118249,"domain_scores_codex":[0.9997833,0.00005225603,0.00002526238,0.00003374994,0.00004484686,0.00006055768],"domain_scores_gemma":[0.9996973,0.0001275809,0.00002853362,0.00005515715,0.00003124137,0.00006026447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004847402,0.00006093299,0.0006853201,0.0000124655,0.00000491107,0.00007872586,0.00008329697,0.00007123115,0.9954115,0.0005021914,0.00009368367,0.002511031],"study_design_scores_gemma":[0.00003147465,0.0003195594,0.01456372,0.000005870403,0.00001497294,0.0005878903,0.00009750538,0.001216749,0.9798752,0.0001633747,0.003118133,0.000005653033],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944741,0.0009062404,0.001101784,0.0000858293,0.00001660537,0.00001753085,0.0004520148,0.000048298,0.002897536],"genre_scores_gemma":[0.9956859,0.0002904825,0.0006743089,0.00004192583,0.000007912219,0.00001827305,0.0009156095,0.00002766259,0.002337784],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002393537,"threshold_uncertainty_score":0.008007228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01543331253293669,"score_gpt":0.2494203677933564,"score_spread":0.2339870552604197,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}