{"id":"W2045143786","doi":"10.1126/science.1081578","title":"Dilated Cardiomyopathy and Heart Failure Caused by a Mutation in Phospholamban","year":2003,"lang":"en","type":"article","venue":"Science","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":628,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Phospholamban; Heart failure; Dilated cardiomyopathy; Cardiomyopathy; Missense mutation; Internal medicine; Phosphorylation; Biology; Ryanodine receptor 2; Endocrinology; Mutation; Cell biology; Calcium; Medicine; Ryanodine receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002939487,0.00005843743,0.0001329036,0.00007439215,0.00008274125,0.0000124032,0.00002319496,0.00003635931,0.00001214628],"category_scores_gemma":[0.0001437436,0.00005047083,0.00002183079,0.0005746749,0.0002612463,0.0001021483,0.000009081859,0.0001162087,0.000009415855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000038587,"about_ca_system_score_gemma":0.0001299964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001788526,"about_ca_topic_score_gemma":0.000006217644,"domain_scores_codex":[0.999336,0.00002957434,0.00007627838,0.000226663,0.0001294964,0.000201957],"domain_scores_gemma":[0.999747,0.00001762564,0.00001517701,0.0001128879,0.00003598086,0.00007136587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0000207249,0.00001935012,0.01694857,0.000007610948,0.000004149566,0.00009428505,0.0003080231,0.00001908681,0.9812699,0.0002098728,0.0005781316,0.0005202832],"study_design_scores_gemma":[0.001919033,0.0004211042,0.5916662,0.00005383467,0.00002726886,0.0008378033,0.0002864649,0.0002849397,0.3945233,0.000603446,0.009142384,0.0002341729],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985255,0.0004790291,0.00002046261,0.0004231663,0.0000612514,0.000130294,0.00000154919,0.00001633074,0.0003423923],"genre_scores_gemma":[0.9994142,0.00001155386,0.0001790983,0.0002976074,0.00001114073,0.000006564642,0.000003020028,0.000003468323,0.00007336822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5867466,"threshold_uncertainty_score":0.2058141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004600752519855992,"score_gpt":0.2381612044642429,"score_spread":0.2335604519443869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}