{"id":"W2045170985","doi":"10.1021/bi100659s","title":"Catalytic Role of the Conformational Change in Succinyl-CoA:3-Oxoacid CoA Transferase on Binding CoA,","year":2010,"lang":"en","type":"article","venue":"Biochemistry","topic":"Neurological diseases and metabolism","field":"Neuroscience","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Thioester; Chemistry; Covalent bond; Transferase; Enzyme; Stereochemistry; Active site; Conformational change; Catalysis; Thiol; Active center; Enzyme catalysis; Cysteine; Substrate (aquarium); Biochemistry; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007114382,0.0001162956,0.0001228519,0.00002874565,0.000064788,0.00001690839,0.0003108766,0.00009270845,0.000106796],"category_scores_gemma":[0.0002541905,0.00008229465,0.00008641609,0.0001655724,0.0001363791,0.00006170766,0.00004560811,0.0002664007,0.00002242943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008403649,"about_ca_system_score_gemma":0.00004654787,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002204087,"about_ca_topic_score_gemma":0.000004971628,"domain_scores_codex":[0.9991257,0.000021715,0.0001866845,0.0002233013,0.000240452,0.0002021244],"domain_scores_gemma":[0.9994772,0.00008544591,0.00006183029,0.0002681736,0.00001609348,0.00009126488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003906324,0.0001109474,0.001117704,0.00002567305,8.24559e-7,0.000003958949,0.00006158074,0.000001227968,0.9969085,0.0009316643,0.00003110732,0.0007676742],"study_design_scores_gemma":[0.0003718802,0.00001770113,0.01130487,0.00001575611,0.000006778156,0.000008563776,0.00001958313,0.0001520395,0.986996,0.00008706353,0.0009286492,0.00009110761],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965767,0.00003336712,3.714569e-7,0.0003277804,0.0001969204,0.0001777672,0.0002580069,0.00001863362,0.002410469],"genre_scores_gemma":[0.9987704,0.00001785697,0.000002776721,0.000983061,0.00008929126,0.0000275198,0.00001245142,0.000007181081,0.00008945222],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01018717,"threshold_uncertainty_score":0.3355879,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02113801283119268,"score_gpt":0.2526307449018139,"score_spread":0.2314927320706212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}