{"id":"W2045181115","doi":"10.1158/0008-5472.can-05-3719","title":"Hypoxia-Inducible Factor-1-Dependent Repression of <i>E-cadherin</i> in von Hippel-Lindau Tumor Suppressor–Null Renal Cell Carcinoma Mediated by TCF3, ZFHX1A, and ZFHX1B","year":2006,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":408,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"U.S. Public Health Service; National Cancer Institute; National Institutes of Health; University of Pennsylvania; York University; Johns Hopkins University","keywords":"Cadherin; Biology; Cancer research; Null cell; Suppressor; Hypoxia-inducible factors; Tumor suppressor gene; Small hairpin RNA; Psychological repression; Renal cell carcinoma; Transcription factor; Cell; Cancer; Gene expression; Gene; Pathology; Carcinogenesis; Medicine; RNA; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001223335,0.0001422345,0.0001365398,0.0001989237,0.0001362998,0.0002156525,0.0001543275,0.0001100107,0.0008949208],"category_scores_gemma":[0.0001013428,0.000129156,0.0001378714,0.00008352638,0.0002262978,0.00009270783,0.00009090298,0.0002526457,0.0002260804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003902397,"about_ca_system_score_gemma":0.0002484202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00182865,"about_ca_topic_score_gemma":0.002113525,"domain_scores_codex":[0.9999168,0.0000141746,0.000006515694,0.00001244413,0.00002609638,0.00002396461],"domain_scores_gemma":[0.9999344,0.000009216443,0.00001844475,0.000007290925,0.000005979972,0.00002458811],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000055773,0.00001177278,0.0001820108,0.000008804143,0.00000227649,0.00003273917,0.000005119661,0.00003713891,0.999211,0.0001023472,0.00002497286,0.0003260694],"study_design_scores_gemma":[0.00001979717,0.00008819379,0.008259999,0.000001822418,0.000009437484,0.0003470407,0.00001321128,0.001221664,0.9887841,0.00005992743,0.001191816,0.000002946246],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983557,0.0003329017,0.0006545571,0.00004164306,0.000008199707,0.000004175056,0.0001073206,0.00003590031,0.0004595598],"genre_scores_gemma":[0.9976351,0.0002064071,0.0004848841,0.00001816471,0.000003933125,0.000007858839,0.0002529553,0.00001221833,0.001378455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00182865,"threshold_uncertainty_score":0.003636062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02422788873021449,"score_gpt":0.304691158773868,"score_spread":0.2804632700436535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}