{"id":"W2045248644","doi":"10.1016/j.mrfmmm.2006.09.009","title":"Histone modifications in response to DNA damage","year":2007,"lang":"en","type":"review","venue":"Mutation research. Fundamental and molecular mechanisms of mutagenesis","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":109,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"Canadian Institutes of Health Research","keywords":"Chromatin; Chromatin remodeling; Histone-modifying enzymes; Histone; Histone code; Cell biology; Biology; DNA repair; Epigenomics; Histone H2A; Genetics; Computational biology; DNA; Nucleosome; Gene; Gene expression; DNA methylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.003208487,0.0004648914,0.0008538091,0.001424371,0.0001508277,0.0000715295,0.0005392929,0.0005192937,0.00004454104],"category_scores_gemma":[0.0004486233,0.0004883065,0.0003153116,0.0009412953,0.0001826209,0.00001308392,0.000577267,0.0003060334,0.00004202607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002444246,"about_ca_system_score_gemma":0.0004273183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007947353,"about_ca_topic_score_gemma":0.00005034425,"domain_scores_codex":[0.9954726,0.001144091,0.0008631577,0.001048178,0.0008249528,0.000647003],"domain_scores_gemma":[0.9982115,0.0001481165,0.0002412419,0.0008244878,0.0002342464,0.0003404255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003480868,0.0003197836,2.913999e-7,0.001882834,0.0001453856,0.0002221007,0.0001337128,0.00001880104,0.7907277,0.001790998,0.0001078766,0.2043025],"study_design_scores_gemma":[0.001215629,0.002172095,0.00003381239,0.0024835,0.0002679259,0.0001490022,0.001168855,0.00003776257,0.547473,0.001674234,0.4421242,0.00119993],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.07447524,0.896978,0.02360386,0.0001509035,0.0002115355,0.003803102,0.0003174022,0.00004343142,0.0004165621],"genre_scores_gemma":[0.07062162,0.9048014,0.01911137,0.0002921431,0.0000841508,0.001396355,0.0012027,0.000353462,0.002136797],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.4420164,"threshold_uncertainty_score":0.9997569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07417949492342174,"score_gpt":0.4116748626574919,"score_spread":0.3374953677340701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}