{"id":"W2045283564","doi":"10.1016/j.mce.2014.12.013","title":"The Keap1-Nrf2-antioxidant response element pathway: A review of its regulation by melatonin and the proteasome","year":2014,"lang":"en","type":"review","venue":"Molecular and Cellular Endocrinology","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":243,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"","keywords":"Melatonin; KEAP1; Proteasome; Ubiquitin ligase; Proteasome inhibitor; Oxidative stress; Superoxide dismutase; Antioxidant; Ubiquitin; Biochemistry; Biology; Chemistry; Cell biology; Transcription factor; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00141767,0.0004701889,0.001480264,0.0001041369,0.0003050969,0.00005406811,0.0004154604,0.000188473,0.00002282734],"category_scores_gemma":[0.001037488,0.0002667031,0.000398944,0.0002692057,0.000719931,0.00003965369,0.0002853658,0.0005089135,0.00002497994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003521375,"about_ca_system_score_gemma":0.0001567551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003875971,"about_ca_topic_score_gemma":4.388344e-7,"domain_scores_codex":[0.9936669,0.003706323,0.000949667,0.0007405666,0.0003635619,0.0005730127],"domain_scores_gemma":[0.9974029,0.000875321,0.0007184384,0.0008325261,0.00005552218,0.0001153107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002460673,0.0000630034,8.958855e-7,0.03763257,0.000168886,0.0002533801,0.0001010547,3.128468e-7,0.03455935,0.3790854,0.0005252498,0.5473638],"study_design_scores_gemma":[0.0006557148,0.00009693005,0.000001005943,0.007036808,0.0003620843,0.000653982,0.000005147062,0.00001567682,0.06094481,0.0002654792,0.9297013,0.0002610181],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006760922,0.9947408,0.0002095246,0.0008229665,0.0001449199,0.002906215,0.00004286817,0.00002834957,0.0004282552],"genre_scores_gemma":[0.00294512,0.9951615,0.0000122383,0.000444585,0.00003155132,0.0005121008,0.00001570501,0.00005356736,0.0008236677],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9291761,"threshold_uncertainty_score":0.9999785,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01595191630827434,"score_gpt":0.2655539406146429,"score_spread":0.2496020243063686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}