{"id":"W2045298852","doi":"10.1002/hep.25636","title":"Presence of precore and core promoter mutants limits the probability of response to peginterferon in hepatitis B e antigen-positive chronic hepatitis B","year":2012,"lang":"en","type":"article","venue":"Hepatology","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Virology; Chronic hepatitis; Antigen; Mutant; Hepatitis B; Medicine; Biology; Immunology; Gene; Genetics; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007714649,0.000226785,0.0007486172,0.0001711355,0.00005849392,0.000003956303,0.0001528459,0.0001564213,0.00007837905],"category_scores_gemma":[0.001504549,0.000171562,0.00006806901,0.0003188952,0.0005808483,0.0001190815,0.0002145837,0.0002404581,0.00001327001],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002023857,"about_ca_system_score_gemma":0.0002135838,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.007287655,"about_ca_topic_score_gemma":0.03461438,"domain_scores_codex":[0.9977872,0.0004800925,0.0006051048,0.0003625892,0.0002341807,0.0005308234],"domain_scores_gemma":[0.9982486,0.0006712676,0.0002013886,0.000496636,0.0002374811,0.0001445617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001336763,0.0002677896,0.9759644,0.0002739623,0.00007314756,0.00003225257,0.00695919,6.93836e-7,0.01094094,0.0001561172,0.0001892316,0.003805566],"study_design_scores_gemma":[0.0006555317,0.001835929,0.9719394,0.0004326563,0.00004472412,0.0001488765,0.00003685497,0.0003508835,0.02392818,0.0001231438,0.000367155,0.0001366209],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947594,0.001369579,0.00005762603,0.001531382,0.0002041601,0.001741302,0.0001009126,0.0000218428,0.0002137609],"genre_scores_gemma":[0.9980785,0.0009057944,0.0005567279,0.0001580479,0.00004880142,0.0001515481,0.000006243466,0.0000239833,0.00007041601],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02732673,"threshold_uncertainty_score":0.9993229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04206053057564835,"score_gpt":0.3114332437863948,"score_spread":0.2693727132107464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}