{"id":"W2045318774","doi":"10.1038/ja.2008.79","title":"A Multivalent Approach to Drug Discovery for Novel Antibiotics","year":2008,"lang":"en","type":"article","venue":"The Journal of Antibiotics","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":51,"is_retracted":false,"has_abstract":false,"ca_institutions":"Johnson & Johnson (Canada)","funders":"","keywords":"Glycopeptide; Antibiotics; Staphylococcus aureus; Microbiology; Chemistry; Vancomycin; Drug discovery; Glycopeptide antibiotic; Cephalosporin; Drug; Peptidoglycan; Antibacterial activity; Bacteria; Biology; Biochemistry; Pharmacology; Cell wall","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004504528,0.0002200935,0.000382337,0.00005227947,0.0002212802,0.00004387007,0.0005780041,0.0001012921,0.0000131058],"category_scores_gemma":[0.0003053251,0.0001469943,0.0002933901,0.0001515015,0.0001504582,0.0001361038,0.00008927203,0.0002989973,0.000003745222],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007150743,"about_ca_system_score_gemma":0.0001132995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007185874,"about_ca_topic_score_gemma":8.639719e-7,"domain_scores_codex":[0.9985974,0.00001740176,0.0005521181,0.0001522192,0.0003631016,0.0003176905],"domain_scores_gemma":[0.9984689,0.0003910323,0.0003710467,0.0004009804,0.0002145188,0.0001535367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003071393,0.0006206048,0.000682041,0.0002207527,0.0001537326,0.00001048204,0.001286605,0.001241286,0.9923462,0.00007913876,0.002953559,0.00009844082],"study_design_scores_gemma":[0.0006822374,0.00003497669,0.0001973309,0.0001363757,0.00016758,0.0005523075,0.001142873,0.0009305013,0.9937909,0.00002737156,0.002122974,0.0002145477],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828518,0.0001226671,0.01204489,0.000391348,0.0001782162,0.00009742491,0.00008729987,0.0000158931,0.004210429],"genre_scores_gemma":[0.988668,0.0002416933,0.006890049,0.0001019751,0.0006181998,1.251648e-8,0.000005342757,0.00003718156,0.003437568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005816148,"threshold_uncertainty_score":0.5994254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0357798396366867,"score_gpt":0.2427952288771032,"score_spread":0.2070153892404165,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}