{"id":"W2045318774","doi":"10.1038/ja.2008.79","title":"A Multivalent Approach to Drug Discovery for Novel Antibiotics","year":2008,"lang":"en","type":"article","venue":"The Journal of Antibiotics","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":51,"is_retracted":false,"has_abstract":false,"ca_institutions":"Johnson & Johnson (Canada)","funders":"","keywords":"Glycopeptide; Antibiotics; Staphylococcus aureus; Microbiology; Chemistry; Vancomycin; Drug discovery; Glycopeptide antibiotic; Cephalosporin; Drug; Peptidoglycan; Antibacterial activity; Bacteria; Biology; Biochemistry; Pharmacology; Cell wall","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003439347,0.0003665632,0.0005710843,0.0005291109,0.0004059815,0.0008986896,0.0009013024,0.0004177391,0.003462913],"category_scores_gemma":[0.0002668715,0.0002527377,0.000451059,0.0003209509,0.0006076292,0.0005941893,0.001306468,0.001071753,0.0008224341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006307196,"about_ca_system_score_gemma":0.0003506022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002580659,"about_ca_topic_score_gemma":0.0004450192,"domain_scores_codex":[0.9998185,0.00003198264,0.00000839011,0.0000406589,0.00006811188,0.00003248183],"domain_scores_gemma":[0.9999247,0.00001922301,0.000009308023,0.00002035038,0.00001189021,0.00001452822],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008103113,0.0002902225,0.0003852898,0.0004027215,0.000134481,0.0002941831,0.00008383506,0.006393774,0.7774425,0.08511309,0.002792719,0.125857],"study_design_scores_gemma":[0.0003497484,0.002005259,0.0006332394,0.00007739397,0.0002669253,0.0007684843,0.00007035373,0.02375355,0.8006135,0.0407129,0.1306753,0.00007324482],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5301746,0.02580457,0.3614173,0.004528551,0.001639299,0.0007578254,0.0006172504,0.001120897,0.07393974],"genre_scores_gemma":[0.8994776,0.008594021,0.06759199,0.001229985,0.0003063027,0.0003751609,0.0002263446,0.0001127468,0.02208579],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003462913,"threshold_uncertainty_score":0.01158458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0357798396366867,"score_gpt":0.2427952288771032,"score_spread":0.2070153892404165,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}