{"id":"W2045328857","doi":"10.1111/j.1399-3011.2005.00252.x","title":"Type and location of fluorescent probes incorporated into the potent <i>μ</i>‐opioid peptide [Dmt<sup>1</sup>]DALDA affect potency, receptor selectivity and intrinsic efficacy*","year":2005,"lang":"en","type":"article","venue":"Journal of Peptide Research","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"National Institute on Drug Abuse","keywords":"Chemistry; Agonist; μ-opioid receptor; Peptide; Tetrapeptide; Dermorphin; Receptor; Oligopeptide; Partial agonist; Stereochemistry; Biodistribution; Opioid peptide; Opioid; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001944429,0.0002119127,0.000402372,0.000320498,0.0003526399,0.000110077,0.0004410925,0.0000916986,0.00001850181],"category_scores_gemma":[0.003475409,0.0001380331,0.00006280022,0.001651058,0.0007221471,0.0003615773,0.0003468908,0.001090036,0.00002458521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001232411,"about_ca_system_score_gemma":0.0004310629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001286226,"about_ca_topic_score_gemma":0.00002693086,"domain_scores_codex":[0.9965106,0.001185771,0.0005872977,0.0004071408,0.0008428888,0.0004662609],"domain_scores_gemma":[0.9965698,0.001015476,0.0003774204,0.0002688501,0.001543495,0.0002249781],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008496786,0.0003277876,0.001431526,0.0001304429,0.00002091171,0.00002308421,0.001013586,0.001006912,0.9590604,0.0003616389,0.002125693,0.03364837],"study_design_scores_gemma":[0.001975546,0.007357144,0.04664076,0.0006188859,0.00005180882,0.0004839399,0.0007315549,0.004358509,0.9244186,0.00141543,0.01152824,0.0004196129],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972914,0.0005941218,0.00001370634,0.001404226,0.00005740959,0.0004676692,0.000002212568,0.00001433407,0.0001548538],"genre_scores_gemma":[0.9967468,0.001993418,0.0004695467,0.0001450311,0.0003914323,0.000005178563,9.267294e-7,0.00002996116,0.0002176781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04520924,"threshold_uncertainty_score":0.5628825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04773662229322174,"score_gpt":0.3254918330813443,"score_spread":0.2777552107881225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}