{"id":"W2045382802","doi":"10.1038/jid.2011.203","title":"Hypothesis Testing: CTLA4 Co-Stimulatory Pathways Critical in the Pathogenesis of Human and Mouse Alopecia Areata","year":2011,"lang":"en","type":"letter","venue":"Journal of Investigative Dermatology","topic":"Hair Growth and Disorders","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Canadian Institutes of Health Research; U.S. Food and Drug Administration; National Institutes of Health; National Alopecia Areata Foundation","keywords":"Alopecia areata; Pathogenesis; Immunology; Medicine; Dermatology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004776741,0.0003924068,0.001392597,0.0006241655,0.00009261045,0.00001616052,0.0003761411,0.0007469727,0.00004899875],"category_scores_gemma":[0.00640403,0.0002684044,0.0002077735,0.0002516831,0.00213259,0.0001092458,0.00005158124,0.001868117,0.000006756918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004351476,"about_ca_system_score_gemma":0.0005107583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004119775,"about_ca_topic_score_gemma":0.00001418492,"domain_scores_codex":[0.9967832,0.000805863,0.00122931,0.0002877802,0.0004659425,0.0004279301],"domain_scores_gemma":[0.9953725,0.002756118,0.0007623044,0.0003763345,0.0005163698,0.0002163248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.0002574857,0.0006522415,0.123985,0.002994034,0.0005966541,0.02760554,0.008863864,0.000001716305,0.0664591,0.001080797,0.766767,0.0007365814],"study_design_scores_gemma":[0.01515537,0.006524149,0.5716552,0.005350978,0.004373123,0.07001498,0.008700593,0.00009952153,0.1663726,0.08790101,0.06103881,0.002813727],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8820377,0.001300411,0.00001587684,0.1136422,0.00007694963,0.0003574264,0.00008059638,0.00001411186,0.002474757],"genre_scores_gemma":[0.7542568,0.00006478369,0.00245154,0.2426213,0.000471808,0.0000160426,0.00002412352,0.0000693693,0.00002421822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7057282,"threshold_uncertainty_score":0.9999768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1285992628786738,"score_gpt":0.3021760830722621,"score_spread":0.1735768201935883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}