{"id":"W2045493657","doi":"10.1016/j.ejphar.2009.02.016","title":"Metoprolol represses PGC1α-mediated carnitine palmitoyltransferase-1B expression in the diabetic heart","year":2009,"lang":"en","type":"article","venue":"European Journal of Pharmacology","topic":"Cardiovascular Function and Risk Factors","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; Health Canada; U.S. Forest Service; National Institutes of Health; Canadian Diabetes Association","keywords":"Metoprolol; Endocrinology; Internal medicine; Peroxisome proliferator-activated receptor; Diabetic cardiomyopathy; Coactivator; Carnitine; Carnitine O-palmitoyltransferase; Chromatin immunoprecipitation; Psychological repression; Alpha (finance); Receptor; Medicine; Transcription factor; Biology; Gene expression; Promoter; Heart failure; Beta oxidation; Metabolism; Biochemistry; Gene; Cardiomyopathy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001436964,0.0002300485,0.000266275,0.0002076493,0.0002112469,0.0004296092,0.0002127327,0.0001930265,0.001518112],"category_scores_gemma":[0.000189283,0.0002102492,0.0001914388,0.0001246607,0.0002719533,0.0001736522,0.0002407232,0.0006651753,0.0002937583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000318488,"about_ca_system_score_gemma":0.0002272719,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008457727,"about_ca_topic_score_gemma":0.001113077,"domain_scores_codex":[0.9998353,0.00002850372,0.00001171367,0.00004108174,0.00002513181,0.00005829884],"domain_scores_gemma":[0.9998118,0.00003303582,0.00005578839,0.0000194929,0.0000193056,0.00006061863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001771703,0.00006380626,0.0005651938,0.00003333205,0.000007656433,0.0000391857,0.000025712,0.00003498223,0.9956144,0.0001143877,0.00009085595,0.00163873],"study_design_scores_gemma":[0.0003791806,0.0006218274,0.03253331,0.00001849286,0.00006422988,0.0002495353,0.0002139547,0.001518024,0.9606189,0.0002042787,0.003566001,0.00001226654],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972825,0.0007302357,0.0009109897,0.0002543133,0.00006083174,0.000005123755,0.0001901947,0.00003616763,0.000529566],"genre_scores_gemma":[0.9970794,0.0004540101,0.0004959733,0.00009697351,0.00002321928,0.00001207533,0.0002312742,0.00002196195,0.001585225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001518112,"threshold_uncertainty_score":0.005078554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0170773787330708,"score_gpt":0.2838230838926938,"score_spread":0.266745705159623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}