{"id":"W2045502630","doi":"10.1038/gt.2011.214","title":"BRCA1 gene therapy reduces systemic inflammatory response and multiple organ failure and improves survival in experimental sepsis","year":2012,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Vitamin C and Antioxidants Research","field":"Nursing","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; Mount Sinai Hospital; St. Michael's Hospital","funders":"Canadian Institutes of Health Research","keywords":"Sepsis; Multiple organ dysfunction syndrome; Systemic inflammation; Genetic enhancement; Medicine; Inflammation; Peritonitis; Immunology; Organ dysfunction; Perforation; Gene delivery; Systemic inflammatory response syndrome; Biology; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009510109,0.0002498289,0.000297611,0.0001862107,0.0001871905,0.00009438631,0.0001568167,0.0001441857,0.000031689],"category_scores_gemma":[0.00003449585,0.0002095026,0.00004525008,0.0001741504,0.0001564454,0.0003077712,0.00005617488,0.0001815789,0.000009690005],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007482604,"about_ca_system_score_gemma":0.00003337805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008571638,"about_ca_topic_score_gemma":0.00001640905,"domain_scores_codex":[0.9979881,0.0005749213,0.0002753643,0.0003458755,0.0002690562,0.0005467001],"domain_scores_gemma":[0.999246,0.0002064517,0.00007536356,0.0002647831,0.00003630728,0.0001710878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002570205,0.0001256419,0.07090332,0.00001550838,0.00003701475,0.00000635158,0.006676141,7.572622e-7,0.9076894,0.000002719636,0.00004867508,0.01192428],"study_design_scores_gemma":[0.002810801,0.0002824859,0.1655923,0.00003726062,0.000001911798,0.00004839502,0.003284758,0.00003049292,0.8268442,0.000006587935,0.0008312414,0.0002296376],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9685048,0.03014861,0.000002665632,0.0004325318,0.0003176294,0.0005106101,0.00001086324,0.00005924871,0.00001303258],"genre_scores_gemma":[0.9971065,0.002133718,0.0001919663,0.0001086578,0.00027901,0.00003129919,0.000006082184,0.00005893032,0.00008386814],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09468897,"threshold_uncertainty_score":0.8543268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02490253459247692,"score_gpt":0.296297716249083,"score_spread":0.271395181656606,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}