{"id":"W2045502630","doi":"10.1038/gt.2011.214","title":"BRCA1 gene therapy reduces systemic inflammatory response and multiple organ failure and improves survival in experimental sepsis","year":2012,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Vitamin C and Antioxidants Research","field":"Nursing","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; Mount Sinai Hospital; St. Michael's Hospital","funders":"Canadian Institutes of Health Research","keywords":"Sepsis; Multiple organ dysfunction syndrome; Systemic inflammation; Genetic enhancement; Medicine; Inflammation; Peritonitis; Immunology; Organ dysfunction; Perforation; Gene delivery; Systemic inflammatory response syndrome; Biology; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001967154,0.0003238821,0.0005754182,0.0003711887,0.0002018003,0.0002291632,0.0002949245,0.0004290552,0.001762435],"category_scores_gemma":[0.0003180308,0.0001221504,0.000246566,0.0001498581,0.000490902,0.0003006553,0.0001885057,0.0007832634,0.0001844287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002376894,"about_ca_system_score_gemma":0.0003556026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007108786,"about_ca_topic_score_gemma":0.0005913216,"domain_scores_codex":[0.9999261,0.00001794883,0.000004471337,0.00001314229,0.00001437812,0.00002387716],"domain_scores_gemma":[0.9998715,0.00002502767,0.00004065846,0.00001389232,0.00001008005,0.00003883011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01807751,0.0034002,0.001609848,0.0003372449,0.0001209652,0.0002146062,0.0001076826,0.0007166885,0.9196134,0.0004353285,0.001745072,0.05362156],"study_design_scores_gemma":[0.004203429,0.04219362,0.02659834,0.000138569,0.000485895,0.001082876,0.0003364301,0.00312707,0.9118431,0.0008093722,0.009118395,0.000062998],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963847,0.00171204,0.0006976184,0.0004426721,0.00008729644,0.00001616094,0.0001054172,0.00008872429,0.0004652781],"genre_scores_gemma":[0.9939406,0.002459011,0.001004834,0.0002191679,0.00005216472,0.00006313599,0.0002495461,0.00002587498,0.00198576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001762435,"threshold_uncertainty_score":0.005895972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02490253459247692,"score_gpt":0.296297716249083,"score_spread":0.271395181656606,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}