{"id":"W2045507047","doi":"10.1371/journal.ppat.1001069","title":"PKC Signaling Regulates Drug Resistance of the Fungal Pathogen Candida albicans via Circuitry Comprised of Mkc1, Calcineurin, and Hsp90","year":2010,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":337,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; U.S. Public Health Service; Burroughs Wellcome Fund","keywords":"Candida albicans; Ergosterol; Calcineurin; Biology; Protein kinase C; Corpus albicans; Antifungal drug; Microbiology; Protein kinase A; Cell biology; Kinase; Drug resistance; Biochemistry; Transplantation; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001170946,0.0003652782,0.0002817739,0.0003837801,0.0002825769,0.0005374872,0.0002143943,0.0002421654,0.001018654],"category_scores_gemma":[0.0001205681,0.000140678,0.0002076185,0.0003066328,0.0002299921,0.0002237126,0.0002207166,0.0005530292,0.000348099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006367802,"about_ca_system_score_gemma":0.0006382916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001065227,"about_ca_topic_score_gemma":0.002106361,"domain_scores_codex":[0.9998497,0.00001240888,0.00001270791,0.00003146604,0.0000520112,0.00004166665],"domain_scores_gemma":[0.9999096,0.000008290864,0.00003146009,0.000008724672,0.00001783949,0.00002394842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001869801,0.00004250753,0.001015196,0.00005112937,0.000006412604,0.00005160194,0.00001306349,0.0002131691,0.9953435,0.000138392,0.00005510244,0.002882893],"study_design_scores_gemma":[0.00004894657,0.0004219738,0.04529134,0.00001625701,0.00005188369,0.0002994041,0.00007538069,0.002276121,0.9488389,0.0001641403,0.002501346,0.00001419347],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942222,0.002341767,0.000809345,0.0001550917,0.00001989017,0.00002987224,0.0004756681,0.00009905811,0.001847057],"genre_scores_gemma":[0.9954209,0.001942567,0.0008011847,0.0000712546,0.000008259472,0.00002376303,0.0004316862,0.00001118199,0.001289159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001065227,"threshold_uncertainty_score":0.004620254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01090870319194403,"score_gpt":0.2272702220687885,"score_spread":0.2163615188768444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}