{"id":"W2045507047","doi":"10.1371/journal.ppat.1001069","title":"PKC Signaling Regulates Drug Resistance of the Fungal Pathogen Candida albicans via Circuitry Comprised of Mkc1, Calcineurin, and Hsp90","year":2010,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":337,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; U.S. Public Health Service; Burroughs Wellcome Fund","keywords":"Candida albicans; Ergosterol; Calcineurin; Biology; Protein kinase C; Corpus albicans; Antifungal drug; Microbiology; Protein kinase A; Cell biology; Kinase; Drug resistance; Biochemistry; Transplantation; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004115888,0.0002358939,0.0006138458,0.00006907644,0.0001431451,0.000009012074,0.0002205628,0.0001435737,0.0001313114],"category_scores_gemma":[0.0003556072,0.0001706964,0.0002120626,0.0002840637,0.0005107188,0.00005125147,0.00008699157,0.0004327216,0.000002359634],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002868865,"about_ca_system_score_gemma":0.0001824033,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006214156,"about_ca_topic_score_gemma":0.0006671801,"domain_scores_codex":[0.998,0.000116769,0.0005898589,0.0004334021,0.0005244951,0.0003354425],"domain_scores_gemma":[0.9980809,0.0002366629,0.0002962275,0.0008872347,0.0003172189,0.0001817266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001692521,0.0001545637,0.2881814,0.000360789,0.00005629147,0.00002265262,0.0005525314,0.000001154791,0.7101307,0.0001084895,0.00008763079,0.000174567],"study_design_scores_gemma":[0.0009868112,0.000065464,0.5147904,0.0003243151,0.0003075549,0.00001856971,0.0003106252,0.0001317943,0.4822002,0.0003947986,0.0002649453,0.0002045445],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971827,0.0005585994,0.00005642099,0.0003190158,0.0001275124,0.0005277844,0.0002254559,0.00003296599,0.0009695957],"genre_scores_gemma":[0.9980385,0.00003914798,0.0006044202,0.0001163574,0.0001026341,0.00001159487,0.00001415147,0.00003444013,0.001038731],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2279304,"threshold_uncertainty_score":0.6960796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01090870319194403,"score_gpt":0.2272702220687885,"score_spread":0.2163615188768444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}