{"id":"W2045525952","doi":"10.1021/co500020a","title":"One-Pot Isomerization–Cross Metathesis–Reduction (ICMR) Synthesis of Lipophilic Tetrapeptides","year":2014,"lang":"en","type":"article","venue":"ACS Combinatorial Science","topic":"Synthetic Organic Chemistry Methods","field":"Chemistry","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"National Institute on Drug Abuse","keywords":"Chemistry; Tetrapeptide; Isomerization; Metathesis; Combinatorial chemistry; Salt metathesis reaction; Alkylation; Tandem; Stereochemistry; Tripeptide; Reduction (mathematics); Sequence (biology); Organic chemistry; Peptide; Catalysis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001951234,0.0002303971,0.0004137375,0.0001025332,0.0003329359,0.0001217188,0.001178527,0.000167006,0.0004380349],"category_scores_gemma":[0.007803327,0.0002451644,0.0001095327,0.00110135,0.001333246,0.0003779928,0.0002059141,0.0001811246,0.00002760829],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001774955,"about_ca_system_score_gemma":0.0002505354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004591266,"about_ca_topic_score_gemma":3.882033e-7,"domain_scores_codex":[0.9972125,0.00007936368,0.0005377386,0.000678224,0.001026246,0.0004659765],"domain_scores_gemma":[0.9973292,0.0008275497,0.0003585173,0.0009648026,0.0003220086,0.0001979595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002235292,0.0001747702,0.0004181821,0.00007912082,0.0000195111,2.079476e-7,0.0001312103,0.00001095719,0.9642408,0.007077816,0.000006877172,0.02781822],"study_design_scores_gemma":[0.0003151863,0.00002824102,0.0004969921,0.00006624913,0.0000573615,0.000009338782,0.00009637924,0.0001154935,0.9850277,0.01294899,0.0005773721,0.0002606912],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98051,0.00003293348,0.0002765961,0.0001194518,0.001478199,0.00008985752,0.000007941009,0.0001343295,0.01735072],"genre_scores_gemma":[0.9968704,0.00001979205,0.002322967,0.000007933611,0.0005302678,0.00003828511,0.000001875544,0.00003094851,0.0001775406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02755753,"threshold_uncertainty_score":0.9997516,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01745793098498895,"score_gpt":0.2765836046455186,"score_spread":0.2591256736605297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}