{"id":"W2045537488","doi":"10.1038/cgt.2012.15","title":"Human amniotic fluid-derived stem cells expressing cytosine deaminase and thymidine kinase inhibits the growth of breast cancer cells in cellular and xenograft mouse models","year":2012,"lang":"en","type":"article","venue":"Cancer Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Chung-Ang University","keywords":"Cytosine deaminase; Suicide gene; Ganciclovir; Cytotoxic T cell; Cancer research; Prodrug; Thymidine kinase; Biology; Stem cell; Cancer cell; Molecular biology; Chemistry; Genetic enhancement; Herpes simplex virus; In vitro; Cancer; Pharmacology; Virology; Cell biology; Biochemistry; Virus; Human cytomegalovirus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002756331,0.0005924603,0.0004143446,0.0006488631,0.000175156,0.0003169599,0.0003029538,0.0002898882,0.001180597],"category_scores_gemma":[0.0001605865,0.0002096223,0.0003480688,0.0002540849,0.00034336,0.0002105174,0.0001332148,0.000871078,0.0003721196],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003120989,"about_ca_system_score_gemma":0.0004074606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002149078,"about_ca_topic_score_gemma":0.002744341,"domain_scores_codex":[0.9997882,0.00004208283,0.00001510819,0.00002209937,0.00008449343,0.00004800885],"domain_scores_gemma":[0.9997764,0.00005990137,0.00004506048,0.00004124715,0.00001938578,0.00005795119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002512663,0.00009987842,0.000105986,0.00003043486,0.000009531561,0.00003708123,0.00001875474,0.00009046486,0.9973882,0.0001514722,0.0001137304,0.001703265],"study_design_scores_gemma":[0.00001875372,0.0002717744,0.0004226973,0.000002987122,0.00001442377,0.00005194162,0.000009002812,0.0003671501,0.9974635,0.00001978032,0.00135627,0.000001720764],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887761,0.003769332,0.003439154,0.0002212396,0.0001437396,0.00004976887,0.0004722644,0.0002542477,0.002874161],"genre_scores_gemma":[0.9858327,0.00317892,0.002758381,0.00005193496,0.00003830985,0.00006321071,0.0009104396,0.00004805471,0.007117941],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002149078,"threshold_uncertainty_score":0.004273176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02649884374247268,"score_gpt":0.277322393518025,"score_spread":0.2508235497755523,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}