{"id":"W2045537488","doi":"10.1038/cgt.2012.15","title":"Human amniotic fluid-derived stem cells expressing cytosine deaminase and thymidine kinase inhibits the growth of breast cancer cells in cellular and xenograft mouse models","year":2012,"lang":"en","type":"article","venue":"Cancer Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Chung-Ang University","keywords":"Cytosine deaminase; Suicide gene; Ganciclovir; Cytotoxic T cell; Cancer research; Prodrug; Thymidine kinase; Biology; Stem cell; Cancer cell; Molecular biology; Chemistry; Genetic enhancement; Herpes simplex virus; In vitro; Cancer; Pharmacology; Virology; Cell biology; Biochemistry; Virus; Human cytomegalovirus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004372439,0.0003417888,0.0003401975,0.0001079547,0.0001681386,0.00004238943,0.0002759691,0.0001627947,0.00004335059],"category_scores_gemma":[0.000001430117,0.0002682642,0.00007272004,0.0001983934,0.0002926907,0.00002965387,0.0001492443,0.0001738844,7.198344e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005516957,"about_ca_system_score_gemma":0.0001120018,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004297608,"about_ca_topic_score_gemma":0.000194972,"domain_scores_codex":[0.9981139,0.0002533904,0.0003408826,0.0004611199,0.0002405268,0.0005902394],"domain_scores_gemma":[0.9990031,0.0000194928,0.0001464272,0.0004939251,0.000135744,0.0002013647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00104262,0.000154581,0.001091222,0.00006067843,0.00008981611,0.000002234927,0.0007487062,0.0005983431,0.9904907,0.000006035001,0.00007167022,0.005643389],"study_design_scores_gemma":[0.001966061,0.0004368813,0.000602629,0.00005626773,0.00002023631,0.000004771513,0.0001251118,0.0003371377,0.9960499,0.00001943364,0.00007513626,0.0003063883],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9445475,0.05437354,0.0001005193,0.0001454544,0.00007406165,0.0005439064,0.0001965329,0.000009717401,0.000008736795],"genre_scores_gemma":[0.9794215,0.0196273,0.00006570682,0.0002474801,0.0002852549,0.000130196,0.0000166167,0.00007922996,0.0001266962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03487399,"threshold_uncertainty_score":0.9999769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02649884374247268,"score_gpt":0.277322393518025,"score_spread":0.2508235497755523,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}