{"id":"W2045545966","doi":"10.1016/j.virol.2004.10.026","title":"A DNA-launched reverse genetics system for porcine reproductive and respiratory syndrome virus reveals that homodimerization of the nucleocapsid protein is essential for virus infectivity","year":2004,"lang":"en","type":"article","venue":"Virology","topic":"Animal Virus Infections Studies","field":"Agricultural and Biological Sciences","cited_by":93,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"","keywords":"Biology; Porcine reproductive and respiratory syndrome virus; Infectivity; Virology; Virus; Complementary DNA; Viral replication; Reverse genetics; Molecular biology; Nidovirales; Arterivirus; Transfection; Mutant; clone (Java method); Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00063404,0.0008529709,0.0005091386,0.0007965997,0.0004202831,0.0006749002,0.0007186497,0.0009766063,0.002527714],"category_scores_gemma":[0.0006304336,0.0006029541,0.0007170652,0.0002739773,0.0006748732,0.0004890705,0.0004677748,0.002727196,0.001252506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009400792,"about_ca_system_score_gemma":0.0006353187,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001310865,"about_ca_topic_score_gemma":0.002151662,"domain_scores_codex":[0.9994935,0.0001058968,0.00003786398,0.0001577849,0.0001121151,0.0000927814],"domain_scores_gemma":[0.9994214,0.000248153,0.000092229,0.00009311118,0.00003654958,0.0001085706],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006833235,0.00004343688,0.000051486,0.00001752502,0.000004762446,0.00002663384,0.00001631118,0.00003324975,0.9986765,0.0002366958,0.00004868738,0.0007764015],"study_design_scores_gemma":[0.00005678123,0.0002412681,0.00105333,0.000007307452,0.00002781364,0.000230481,0.00001654495,0.001358196,0.9944503,0.0001125465,0.002432073,0.00001339859],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9456912,0.00110607,0.04478041,0.0006710678,0.000354994,0.0004995791,0.001475232,0.001124391,0.00429706],"genre_scores_gemma":[0.9276584,0.0008896436,0.05269605,0.0004303346,0.00008888404,0.0002874917,0.006541432,0.0005506072,0.01085714],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002527714,"threshold_uncertainty_score":0.008456051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02751537853322349,"score_gpt":0.2367618729706139,"score_spread":0.2092464944373904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}