{"id":"W2045601151","doi":"10.4161/21688362.2014.970940","title":"Connecting metabolism to intestinal barrier function: The role of leptin","year":2014,"lang":"en","type":"article","venue":"Tissue Barriers","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotel Dieu Hospital","funders":"","keywords":"Cell biology; Adherens junction; Tight junction; Paracellular transport; Actin cytoskeleton; Leptin; RHOA; Barrier function; Signal transduction; Biology; Intestinal epithelium; Actin remodeling; Cytoskeleton; Cell junction; Intestinal mucosa; Epithelium; Cell; Endocrinology; Internal medicine; Cadherin; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003882589,0.0001106816,0.0001515027,0.0000611064,0.0002924984,0.00003986295,0.0002789366,0.00003958324,0.000952924],"category_scores_gemma":[0.002133472,0.00008382639,0.00004788986,0.000281168,0.00009121434,0.0001110161,0.00008095353,0.0001127492,0.0001969185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001012556,"about_ca_system_score_gemma":0.00002776066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004107874,"about_ca_topic_score_gemma":0.0000108081,"domain_scores_codex":[0.9989219,0.0001536811,0.0002033474,0.0002595286,0.0002576099,0.0002039706],"domain_scores_gemma":[0.9990762,0.0002705295,0.00009629501,0.0003192296,0.00005542882,0.0001823245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005924444,0.000008383436,0.0007957495,0.000006455381,0.000004173644,8.558642e-7,0.001184498,0.0006181994,0.9179204,0.04391691,0.0003344236,0.03515078],"study_design_scores_gemma":[0.000110434,0.00006573548,0.002191637,0.000009076306,0.00001156353,0.000007954427,0.0003814089,0.000520579,0.6153201,0.001790267,0.3795086,0.00008268166],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9760863,0.00005564603,0.003517886,0.0007471489,0.0003362995,0.0002040038,0.000004725906,0.00007572994,0.01897224],"genre_scores_gemma":[0.997779,0.000001278394,0.0003923655,0.0007568244,0.0002154831,0.000008005553,5.767647e-7,0.00001405732,0.0008323995],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3791741,"threshold_uncertainty_score":0.9999604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01187675382601859,"score_gpt":0.2443266798820905,"score_spread":0.232449926056072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}