{"id":"W2045625530","doi":"10.1021/ja0567687","title":"<i>O</i>-GlcNAcase Catalyzes Cleavage of Thioglycosides without General Acid Catalysis","year":2005,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Michael Smith Health Research BC","keywords":"Chemistry; Hydrolysis; Catalysis; Nucleophile; Acid catalysis; Glycoside; Kinetic isotope effect; Threonine; Aryl; Transition state; Organic chemistry; Stereochemistry; Enzyme catalysis; Serine; Medicinal chemistry; Deuterium; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002528541,0.0002474799,0.0006927002,0.00001558193,0.00009102182,0.00002762742,0.0008213508,0.000111365,0.0001232389],"category_scores_gemma":[0.0002122293,0.0001694777,0.001435156,0.0003318123,0.0007335382,0.0001358528,0.0001909336,0.0005664655,0.00000326417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000209938,"about_ca_system_score_gemma":0.000108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007230939,"about_ca_topic_score_gemma":0.000002379559,"domain_scores_codex":[0.9981746,0.00002674627,0.0007324624,0.0002119566,0.0005426257,0.0003115893],"domain_scores_gemma":[0.9976193,0.0001542548,0.001368543,0.0005312216,0.0001479012,0.0001788172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009112203,0.0001678524,0.002963312,0.00005379879,0.0003470301,0.000003568802,0.0004213102,0.00002966402,0.9866934,0.000002070348,0.006388769,0.002838146],"study_design_scores_gemma":[0.0003460507,0.00001243788,0.000098138,0.00006007665,0.0002943214,0.0001482667,0.0006541219,0.0001343432,0.9956452,0.00002897632,0.002382901,0.0001951791],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967502,0.0003293663,0.00001842573,0.001178544,0.000035218,0.00002185995,0.00003370621,0.00001733835,0.001615364],"genre_scores_gemma":[0.9951382,0.0001824818,0.003110663,0.0004127912,0.0008237264,0.000002509909,0.000005065703,0.00002927768,0.0002953151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008951831,"threshold_uncertainty_score":0.6911102,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00844780597934675,"score_gpt":0.2353356422291978,"score_spread":0.2268878362498511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}