{"id":"W2045648679","doi":"10.1158/0008-5472.can-04-3671","title":"Prostaglandin E2 Enhances Intestinal Adenoma Growth via Activation of the Ras-Mitogen-Activated Protein Kinase Cascade","year":2005,"lang":"en","type":"article","venue":"Cancer Research","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":192,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute","keywords":"Prostaglandin E2; Cancer research; Protein kinase A; Tumor promotion; Biology; Kinase; Prostaglandin E; Endocrinology; Prostaglandin; Mitogen-activated protein kinase; Signal transduction; Internal medicine; Cell growth; Cyclooxygenase; Cell biology; Cancer; Enzyme; Medicine; Carcinogenesis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001127329,0.0003002612,0.0001735048,0.0003186815,0.00009710994,0.0001914368,0.00007024368,0.0001535213,0.002200885],"category_scores_gemma":[0.0001613431,0.0001043214,0.0002217669,0.0001105876,0.0001920256,0.0001444482,0.0001695738,0.0003794338,0.0002920748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001605666,"about_ca_system_score_gemma":0.0001676951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004585852,"about_ca_topic_score_gemma":0.001201889,"domain_scores_codex":[0.9998899,0.00003962649,0.000007201629,0.000007317229,0.00003000421,0.00002597966],"domain_scores_gemma":[0.9998943,0.00002911412,0.00001926654,0.0000111045,0.000008335308,0.00003781892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001116743,0.0001689561,0.0003267032,0.00006560006,0.00000735862,0.0001017192,0.00001709774,0.00005836142,0.9947935,0.00009518691,0.00005717021,0.003191585],"study_design_scores_gemma":[0.0001744205,0.004910634,0.01479101,0.00000918867,0.00002539957,0.0003779707,0.00005891327,0.0007147444,0.9749501,0.0001178538,0.003862179,0.000007516142],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944401,0.00156733,0.0006571909,0.0001297171,0.00003523227,0.00002614233,0.0001174345,0.00006168296,0.002965338],"genre_scores_gemma":[0.9946933,0.00133326,0.0008758515,0.00003704203,0.0000191156,0.00001718675,0.0001193384,0.000006867363,0.002898037],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002200885,"threshold_uncertainty_score":0.007362664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03823075063330117,"score_gpt":0.3545545471805322,"score_spread":0.316323796547231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}