{"id":"W2045650548","doi":"10.1021/bi992432w","title":"Conformational Difference between PDE4 Apoenzyme and Holoenzyme","year":2000,"lang":"en","type":"article","venue":"Biochemistry","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Cofactor; Affinities; Rolipram; Förster resonance energy transfer; Enzyme; Stereochemistry; Phosphodiesterase; Binding site; Oxidoreductase; Biochemistry; Fluorescence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006396172,0.0001165189,0.00008491113,0.00001124347,0.00008133735,0.00002672163,0.00007571909,0.000144794,0.000233467],"category_scores_gemma":[0.000019202,0.0001088885,0.00003554575,0.00003608385,0.00009509608,0.000003734469,0.00003150845,0.00005635121,0.00002503341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008181254,"about_ca_system_score_gemma":0.0000332479,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003656391,"about_ca_topic_score_gemma":5.579922e-7,"domain_scores_codex":[0.9993977,0.00001326466,0.0001432272,0.0002129601,0.00009616557,0.0001366586],"domain_scores_gemma":[0.9996539,0.000008389427,0.00003765897,0.0001782017,0.0000316228,0.00009020339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009512086,0.00003834968,0.01290607,0.00004335694,0.00005255531,0.000001196779,0.00004131222,0.000007515882,0.9476969,0.00004295124,0.009379593,0.02969505],"study_design_scores_gemma":[0.000543159,0.00005412352,0.05864868,0.0000146811,0.00001351338,0.00003179548,0.00002178053,0.00008527011,0.8991209,0.00005063093,0.04118688,0.0002285781],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952571,0.0003845346,0.0002018261,0.000157812,0.00003839455,0.00005449993,0.00004036974,0.00002002033,0.003845407],"genre_scores_gemma":[0.9884198,0.00009734486,0.0001345355,0.0002401773,0.0002857971,0.000008295792,0.0005278596,0.000008318036,0.01027784],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04857603,"threshold_uncertainty_score":0.4440346,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006945119738277647,"score_gpt":0.2169341804575235,"score_spread":0.2099890607192459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}