{"id":"W2045650548","doi":"10.1021/bi992432w","title":"Conformational Difference between PDE4 Apoenzyme and Holoenzyme","year":2000,"lang":"en","type":"article","venue":"Biochemistry","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Cofactor; Affinities; Rolipram; Förster resonance energy transfer; Enzyme; Stereochemistry; Phosphodiesterase; Binding site; Oxidoreductase; Biochemistry; Fluorescence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003507309,0.0003660809,0.000344702,0.0001334343,0.000128123,0.0007007201,0.0006461747,0.0003599788,0.001668384],"category_scores_gemma":[0.0006482333,0.0002517591,0.0003390174,0.0001008985,0.0003502945,0.0004676266,0.000205105,0.000707642,0.0006053261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005545809,"about_ca_system_score_gemma":0.0002020757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006026582,"about_ca_topic_score_gemma":0.0004605449,"domain_scores_codex":[0.9997017,0.00002945307,0.00002957435,0.0001391635,0.00005016222,0.00004990008],"domain_scores_gemma":[0.9997323,0.00007803643,0.00005571903,0.00003425775,0.00004409446,0.0000555529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003635437,0.00004727955,0.001130478,0.00007330542,0.00003620896,0.00009630009,0.00005355825,0.0001197109,0.9951718,0.0003105811,0.00006007096,0.002537158],"study_design_scores_gemma":[0.00005744228,0.0002497989,0.01167693,0.00001288022,0.00004729956,0.0005289473,0.00005707441,0.00190106,0.982787,0.0001927239,0.002468399,0.00002047514],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888029,0.001997117,0.007316939,0.0001539656,0.00003827704,0.00003020775,0.0003096494,0.00008406678,0.001266933],"genre_scores_gemma":[0.9907438,0.0008080671,0.004593774,0.000165727,0.00001523876,0.00004659496,0.001062721,0.00004619502,0.002517847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001668384,"threshold_uncertainty_score":0.005581319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006945119738277647,"score_gpt":0.2169341804575235,"score_spread":0.2099890607192459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}